Evidence map›Paper›PMID 40384011›Full record

ArticleBrain and behavior2025

Causal Relationships Between the Gut Microbiota, Inflammatory Cytokines, and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Analysis.

Li Changqing, Yu Leying, Ma Caiyun, Wen Hebao, Han Laiguo, Zhao Xiaojiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li ChangqingDepartment of Physical Education and Arts, Bengbu Medical University, Bengbu, China.
Yu LeyingDepartment of Physical Education and Arts, Bengbu Medical University, Bengbu, China.
Ma CaiyunAnhui Engineering Research Center for Neural Regeneration Technology and Medical New Materials, Bengbu Medical University, Bengbu, China.
Wen HebaoDepartment of Physical Education and Arts, Bengbu Medical University, Bengbu, China.
Han LaiguoDepartment of Physical Education and Arts, Bengbu Medical University, Bengbu, China.
Zhao XiaojiangDepartment of Physical Education and Arts, Bengbu Medical University, Bengbu, China.ORCID https://orcid.org/0000-0001-6972-9260

Funding

innovation and entrepreneurship training program for college studentsNational College Students Innovation and Entrepreneurship Training Program 202310367042Natural Science Foundation of the Higher Education Institutions of Anhui ProvincePhilosophy and Social Sciences Foundation of the Anhui Higher Education Institutions of ChinaProvincial Quality Engineering Project of Higher Education Institutions of Anhui Province
6 · The paper itself

Abstract

backgroundThe relationship between gut microbiota (GM) and amyotrophic lateral sclerosis (ALS) is well-documented. However, the causal nature of this association and the potential mediating role of inflammatory cytokines (ICs) have yet to be elucidated.

methodsWe performed Mendelian randomization (MR) analyses utilizing data derived from genome-wide association studies (GWAS) of GM, ICs, and ALS. Initially, we conducted bidirectional two-sample MR analysis to determine the causal relationships between GM, ICs, and ALS. Subsequently, a two-step MR mediation analysis was performed to investigate the role of ICs as mediators. The primary statistical approach was the inverse variance weighted (IVW) method.

resultsThrough MR analysis, we identified one positive causal relationship and three negative causal relationships between GM and ALS. There was one positive association and one negative association between ICs and ALS. In addition, ICs do not appear to mediate the pathway from GM to ALS.

conclusionThis study established a causal relationship between GM, ICs, and ALS, suggesting that ICs do not function as mediators in the pathway from GM to ALS. These findings provide new perspectives on potential ALS prevention and treatment strategies.

Indexed as

Amyotrophic Lateral SclerosisCytokinesGastrointestinal MicrobiomeGenome-Wide Association StudyHumansInflammationMendelian Randomization AnalysisCytokinesAmyotrophic Lateral SclerosisGut microbiotainflammatory cytokinesMendelian randomization

Identifiers

PMID40384011
PMCPMC12086303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.