Evidence map›Paper›PMID 40383936›Full record

ArticleSubstance use & misuse2025

Prescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors.

Laya Jalilian-Khave, Elina A Stefanovics, Zu Wei Zhai, Marc N Potenza

Abstract read
In one paragraph

Article in Substance use & misuse, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Laya Jalilian-KhaveDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-7163-7776
Elina A StefanovicsDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Zu Wei ZhaiProgram in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Marc N PotenzaDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Julie Dragon · 2012 to 2026
$58.4M
Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
NIDA NIH HHS T32 DA022975NIGMS NIH HHS P20 GM103449
6 · The paper itself

Abstract

backgroundOpioid misuse is a public health crisis in the United States and globally, impacting adolescents. Prescription pain medication misuse (PPMM) may promote transitioning to heroin use (HU). Understanding relationships between types of opioid misuse (PPMM with and without HU) and seemingly positive (e.g., routine healthcare participation, family support, academic performance) and negative (e.g., violent and other risky behaviors) measures can help address these concerns.

objectivesThe current study explored PPMM and HU in high-school students, focusing on factors such as routine healthcare participation, family support, and academic performance, and violent and risky behaviors.

methodsUsing the Youth Risk Behavior Survey data, we compared adolescents misusing prescription pain medications with and without HU and those without either, using chi-square analyses and adjusted odds ratios to understand their relationships with positive and negative measures.

resultsOf 1931 high-school respondents, 180 (8.8%) reported PPMM without HU (PPMM+), 28 (1.4%) reported HU with PPMM (PPMM/HU+), and 1723 (89.80%) reported no PPMM or HU (PPMM-). Adjusted models showed PPMM+ adolescents had lower odds of strong family support and higher odds of specific violent and risky behaviors compared to PPMM-. PPMM/HU+ versus PPMM+ respondents showed lower odds of healthcare participation, family support, and academic performance, and higher odds of specific violent and risky behaviors. Differences were particularly robust between PPMM/HU+ and PPMM- adolescents.

conclusionFindings suggest PPMM+ and PPMM/HU+ correlate with negative health and functioning in adolescents. Addressing HU requires focusing on specific measures including healthcare utilization, academic performance, and risky behaviors.

Indexed as

Academic PerformanceAdolescent BehaviorHeroin DependencePrescription Drug MisuseRisk-TakingViolenceAdolescentFamily SupportFemaleHumansMaleSocial SupportUnited Statesaddictive behavioradolescentseducationfamily supporthealthcare accessheroin usehigh-risk behaviorOpioid misusesubstance useviolence

Identifiers

PMID40383936
PMCPMC12187537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.