ArticleJournal of Parkinson's disease2024
Decline of olfactory function in Parkinson's disease: A ten-year longitudinal study.
Article in Journal of Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between olfactory dysfunction and structural MRI findings in Parkinson's disease: a systematic review.Brain imaging and behavior · 2026Pooled it
- Olfactory dysfunction as a marker of neurodegenerative disease in older adults.Aging clinical and experimental research · 2026Article
- Olfaction function improves in a specialised unit for Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Observational
- Olfactory function is longitudinally associated with semantic fluency in Parkinson's disease: a cohort study.Journal of neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundOlfactory dysfunction is a prodromal sign of Parkinson's disease (PD) present in up to 90% of patients. However, it is unclear whether or not olfactory function worsens over the course of the disease.ObjectiveIn this study we examined whether the rate of decline of olfactory function in PD patients exceeds the expected age-related decline.MethodsOlfactory function was tested in 90 PD patients at baseline (age at baseline 58.3 years, 68.9% males) and an average 10 years later using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). To screen for concomitant cognitive deficits as a potential confounder, the Mini-Mental State Examination (MMSE) was used.ResultsAt baseline, the mean UPSIT score was 22 points. Over the average 10-year follow-up period olfactory function decreased in 81.1% of PD patients, even in the youngest patients in whom no age-related decline was expected. The mean decrease was six UPSIT points (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.