Evidence map›Paper›PMID 40383858›Full record

ArticleScientific reports2025

Solasodine suppresses nasopharyngeal carcinoma progression by inducing ferroptosis.

Jing Wang, DongHua Wang, SiQing Ma, BinSheng He, JiaoYang Lu, Zhen Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing WangHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha, 410219, China.
DongHua WangSchool of Nursing, Changsha Medical University, Changsha, 410219, China.
SiQing MaDepartment of Pharmacy, Hunan Chest Hospital, Changsha, 410013, China.
BinSheng HeHunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha, 410219, China.
JiaoYang LuHunan Provincial Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China. joyerlu@qq.com.
Zhen GuoHunan Provincial Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219, China. plws3298@163.com.

Funding

Changsha Outstanding Innovative Youth Training Plan No.kq2209024ESI Discipline Special Project of Changsha Medical University No.2022CYY007ESI Discipline Special Project of Changsha Medical University No.2022CYY028ESI Discipline Special Project of Changsha Medical University No.2022CYY041National Natural Science Foundation of China No.32201108National Natural Science Foundation of China No.82104309Natural Science Foundation of Hunan Province No.2023JJ20042Natural Science Foundation of Hunan Province No.2024JJ5053Outstanding Youth Project of Hunan Provincial Education Department No.24B0890Outstanding Youth Project of Hunan Provincial Education Department No.24B0892Outstanding Youth Project of Hunan Provincial Education Department No.24B0893The Science and Technology Innovation Program of Hunan Province No.2022RC1167The Science and Technology Innovation Program of Hunan Province No.2023RC3194Training Plan for Young Backbone Teachers in Hunan Province No.2022214
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high prevalence in China. Solasodine is a natural compound derived from the traditional herb that possess anticancer activity in various tumors, but its role in NPC remains unclear. Here, we demonstrated that solasodine potently suppressed NPC growth and induced cell death both in vitro and in vivo. Network pharmacology identified HMOX1 as a pivotal target of solasodine linked to ferroptosis. Solasodine triggered ferroptotic hallmarks, including mitochondrial cristae disruption, elevated Fe

Indexed as

CarcinomaFerroptosisNasopharyngeal NeoplasmsSolanaceous AlkaloidsAnimalsCell Line, TumorCell ProliferationDisease ProgressionHumansMiceNasopharyngeal CarcinomaReactive Oxygen SpeciesXenograft Model Antitumor AssaysReactive Oxygen SpeciesSolanaceous AlkaloidssolasodineCell deathFerroptosisNasopharyngeal carcinomaNetwork pharmacologySolasodine

Identifiers

PMID40383858
PMCPMC12086188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.