Evidence map›Paper›PMID 40383843›Full record

ArticleProgress in orthodontics2025

Compressive force-induced succinate production via metabolic reprogramming in periodontal ligament cells promotes orthodontic tooth movement.

Jiahong Shi, Lulu Wang, Liliang Shan, Meng Zhu, Yu Chen, Houxuan Li, Lang Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiahong Shi *Department of Periodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Lulu Wang *Department of Orthodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Liliang ShanDepartment of Periodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Meng ZhuDepartment of Orthodontics, Stomatology Hospital of General Hospital, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.
Yu ChenDepartment of Dentistry, People's Hospital of Longhua, Shenzheng, China.
Houxuan LiDepartment of Periodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China. lihouxuan3435_0@163.com.
Lang LeiDepartment of Orthodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China. leilangdental@163.com.

Funding

Nanjing Medical Science and Technique Development Foundation YKK24197National Natural Science Foundation of China 82371007
6 · The paper itself

Abstract

objectiveThis study aimed to elucidate metabolic alterations in gingival crevicular fluid (GCF) during orthodontic tooth movement (OTM) and investigate the role of the succinate-SUCNR1 axis in bone resorption and tooth movement.

resultsOTM was accompanied by the change of TCA cycle and increase of succinate in the human GCF. Succinate accumulation was observed in periodontal ligament cells (PDLCs) under compressive force, accompanied by increase of glycolysis and decrease of succinic dehydrogenase activity. Suppression of the succinate-SUCNR1 axis reduced osteoclastogenesis in BMDMs. OTM slowed down in the SUCNR1

conclusionOTM is accompanied by the increase of succinate in periodontal tissues. Compressive force induces metabolic reprogramming in PDLCs, leading to enhanced succinate production. Succinate promotes macrophage migration and osteoclast differentiation via the SUCNR1 axis, ultimately facilitating orthodontic tooth movement. These findings provide a new potential therapeutic target for regulating periodontal tissue remodeling during orthodontic treatment.

Indexed as

Gingival Crevicular FluidPeriodontal LigamentSuccinic AcidTooth Movement TechniquesAnimalsCell DifferentiationCitric Acid CycleGlycolysisHumansMaleMetabolic ReprogrammingMiceMice, Inbred C57BLOsteoclastsOsteogenesisSuccinate DehydrogenaseSuccinate DehydrogenaseSuccinic AcidBone remodelingGingival crevicular fluidOrthodontic tooth movementSuccinateSuccinate receptor

Identifiers

PMID40383843
PMCPMC12086132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.