ArticlePediatrics2025
Oral Nicotine Product Use and Vaping Progression Among Adolescents.
Article in Pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Oral Nicotine Product Use and E-Cigarette Use Persistence in Adolescents and Young Adults: An Analysis Using Augmented Inverse Probability Weighting.American journal of epidemiology · 2026Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectivesUse of flavored oral nicotine products (ONPs), including nicotine pouches and other ONPs (eg, gums and lozenges) is increasing among adolescents who use e-cigarettes (ie, vape). It is unknown whether ONP use is associated with vaping behaviors.
methodsWe used data from 6 semiannual waves of a prospective cohort of Southern California adolescents (2021-2024). Among participants who used e-cigarettes in the past 6 months at waves 1-5 (n = 703; mean age = 16 years), we examined the time-varying and time-lagged association of ONP use (any ONP, nicotine pouch, other ONPs [eg, gum or lozenges]) at waves 1-5 with subsequent vaping persistence and frequency 6 months later at waves 2-6.
resultsAcross a total of 1173 observations, there were 277(23.7%) observations of any past 6-month ONP use (17.4% nicotine pouch and 21.3% other ONPs). Past 6-month use (vs nonuse) of any ONP (risk ratio [RR] = 0.75; 95% CI, 0.62-0.91), nicotine pouches (RR = 0.43; 95% CI:, 0.32-0.58), and other ONPs (RR = 0.72; 95% CI, 0.59-0.89) was associated with lower likelihood of subsequent vaping persistence. Use of nicotine pouches was also inversely associated with past 30-day vaping frequency at follow-up (incidence rate ratio = 0.43; 95% CI, 0.26-0.72). In secondary analyses (examining ONP use in the past 30 days and restricted to youth reporting past 30-day e-cigarette use at exposure waves), only inverse associations of nicotine pouch use with vaping persistence remained.
conclusionsYouth nicotine pouch use was associated with a lower likelihood of continued vaping and lower vaping frequency 6 months later. ONP use might not increase vaping, and nicotine pouches may serve as a partial nicotine substitute for youth who vape.
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