Evidence map›Paper›PMID 40383501›Full record

ArticleResuscitation2025

Attenuation of mitochondrial dysfunction in a ventricular fibrillation swine model of cardiac arrest treated with carbon monoxide.

Tiffany S Ko, John C Greenwood, Ryan W Morgan, Benjamin S Abella, Frances S Shofer, McKenna Mason, Devora Weintraub, Devesh Bungatavula, Alistair Lewis, Nicolina R Ranieri and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Tiffany S KoResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
John C GreenwoodDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ryan W MorganResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Benjamin S AbellaDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Frances S ShoferDepartment of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
McKenna MasonResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Devora WeintraubResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Devesh BungatavulaDrexel University, Philadelphia, PA 19104, USA.
Alistair LewisDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nicolina R RanieriDivision of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA; School of Biomedical Engineering, Science and Health Systems at Drexel University, Philadelphia, PA 19104, USA.
Arjun G YodhDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Wesley B BakerResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rodrigo M FortiResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shih-Han KaoResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Samuel S ShinDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Todd J KilbaughResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
David H JangResuscitation Science Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: David.Jang@pennmedicine.upenn.edu.

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Improving Pediatric Cardiac Arrest Survival and Neurologic OutcomeR01HL141386 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI KILBAUGH, TODD JUSTEN · 2019 to 2023
$4.4M
The Use of Blood Cells and Optical Cerebral Complex IV Redox States in a Porcine Model of CO Poisoning with Evaluation of Mitochondrial TherapyR01HL166592 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DAVID H JANG · 2023 to 2026
$2.8M
NHLBI NIH HHS R01 HL141386NHLBI NIH HHS R01 HL166592NIBIB NIH HHS P41 EB029460NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

backgroundOut-of-hospital cardiac arrest (OHCA) affects over 360,000 adults in the United States each year with a 50-80% mortality. Despite aggressive supportive care and use of targeted temperature management, half of adults do not live to hospital discharge and nearly one-third of survivors have significant neurologic injury. Development of neuroprotective therapeutics is critical to improving outcomes. One promising readily available agent that has shown benefit is carbon monoxide (CO).

methodsWe utilize a swine model of ventricular fibrillation (VF) arrest to assess the therapeutic effect of CO on cellular measures. All animals underwent VF arrest followed by cardiopulmonary resuscitation until achievement of return of spontaneous circulation (ROSC) or the 20 min mark. One hour following ROSC, animals were randomized to the Cardiac Arrest group (VF alone) versus the CO group (VF treated with CO). Animals in the CO group were administered low dose CO of 200 ppm for two hours. At three hours post-ROSC period, all animals were euthanized for tissue and blood collection for mitochondrial respiration (cortical and hippocampal tissue) and the downstream biomolecular analysis.

resultsThe primary findings were an overall improvement in mitochondrial respiration and ATP concentrations in the brain from animals in the CO group. In addition, we also report the use of cell-free DNA as a biomarker to localize the site of tissue injury and our non-invasive optical monitoring device to assess cerebral metabolism.

conclusionsCO may be a potential therapeutic to attenuate cellular injury in post-arrest.

Indexed as

Carbon MonoxideHeart ArrestMitochondriaOut-of-Hospital Cardiac ArrestVentricular FibrillationAnimalsCardiopulmonary ResuscitationDisease Models, AnimalSwineCarbon MonoxideCell-free DNAMitochondriaSwineToxicology

Identifiers

PMID40383501
PMCPMC12335330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.