Evidence map›Paper›PMID 40383395›Full record

ArticleMucosal immunology2025

Notch-activated basophils support intestinal CD4

Lauren M Webb, Lindsey M Warner, Eric Y Helm, Bridget M Mooney, Pavithra Sundaravaradan, Macy K Matheson, Tighe Christopher, Alejandra Lopez Espinoza, Elia D Tait Wojno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lauren M WebbDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Lindsey M WarnerDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Eric Y HelmDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Bridget M MooneyDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Pavithra SundaravaradanDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Macy K MathesonDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Tighe ChristopherDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Alejandra Lopez EspinozaDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Elia D Tait WojnoDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: etwojno@uw.edu.

Funding

Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine.R01AI130379 · NIAID · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2017 to 2026
$3.5M
The Notch Signaling Pathway Regulates Basophil Responses During Helminth InfectionR01AI132708 · NIAID · UNIVERSITY OF WASHINGTON · PI TAIT WOJNO, ELIA D · 2017 to 2021
$2.1M
Prostaglandin D2 and its receptor CRTH2 regulate intestinal inflammation and homeostasisR01DK134410 · NIDDK · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2023 to 2026
$2.0M
NIAID NIH HHS R01 AI130379NIAID NIH HHS R01 AI132708NIDDK NIH HHS R01 DK134410
6 · The paper itself

Abstract

Helminth infections affect billions of people worldwide and cause substantial morbidity. Intestinal helminth infection provokes Type 2 inflammation orchestrated by CD4

Indexed as

BasophilsCD4-Positive T-LymphocytesIntestinal MucosaIntestinesReceptors, NotchTh2 CellsTrichuriasisTrichurisAnimalsDisease Models, AnimalHumansInterleukin-4MiceMice, Inbred C57BLMice, KnockoutSignal TransductionInterleukin-4Receptors, NotchBasophilCD4 T cellGastrointestinalHelminth infectionType 2 immunology

Identifiers

PMID40383395
PMCPMC12375385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.