Evidence map›Paper›PMID 40383162›Full record

ArticleRespiratory medicine2025

An investigation of causality between obstructive sleep apnea and interstitial lung disease: Insights from two-sample mendelian randomization.

Fei Peng, Zhen Zheng, Chao He, Shangjie Wu, Yong Zhou

Abstract read
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In one paragraph

Article in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fei PengDepartment of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China; John W. Deming Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University, LA, 70112, USA; Postdoctoral Mobile Station of Clinical Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Zhen ZhengJohn W. Deming Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University, LA, 70112, USA.
Chao HeDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Shangjie WuDepartment of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yong ZhouJohn W. Deming Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University, LA, 70112, USA. Electronic address: yzhou40@tulane.edu.

Funding

Mechano-niche in Lung Repair after InjuryR01HL156973 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHOU, YONG · 2021 to 2024
$2.4M
NHLBI NIH HHS R01 HL156973
6 · The paper itself

Abstract

backgroundPrevious observational studies have suggested a potential link between obstructive sleep apnea (OSA) and interstitial lung disease (ILD), however, the casual relationship between OSA and ILD remains uncertain.

objectiveThis study aims to rigorously assess the potential causal relationship between OSA and ILD.

methodsThe study utilized genome-wide association studies (GWAS) data on OSA and ILD. Univariable and multivariable Mendelian randomization (MR) were employed to explore the causal relationship. Multiple MR methods such as MR Egger, weighted median, inverse variance weighting (IVW), and weighted mode were used.

resultsUnivariate MR analyses using IVW analysis indicates a potential association between ILD and an increased risk of OSA (Odds ratio (OR) = 1.071, 95 % CI: 1.018 to 1.126, P = 0.007). However, no compelling evidence supports a reverse causal relationship in the findings above. A thorough analysis further validates the reliability of the present study. Following adjustment for the effects of smoking and BMI in multivariate MR analyses, ILD still has a positive independently association with OSA risk (OR = 1.117, 95 % CI: 1.018 to 1.225, P = 0.020).

conclusionsOur study identifies ILD as a causal risk factor for OSA, providing the evidence for the prevention and treatment of the disease.

Indexed as

Lung Diseases, InterstitialMendelian Randomization AnalysisSleep Apnea, ObstructiveBody Mass IndexCausalityFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsCausalityInterstitial lung diseaseMendelian randomizationObstructive sleep apnea

Identifiers

PMID40383162
PMCPMC12981078

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.