Evidence map›Paper›PMID 40383131›Full record

ArticleThe Lancet. Respiratory medicine2025

General population-based lung function trajectories over the life course: an accelerated cohort study.

Judith Garcia-Aymerich, Martí de Las Heras, Anne-Elie Carsin, Simone Accordini, Alvar Agustí, Dinh Bui, Shyamali C Dharmage, James W Dodd, Ikenna Eze, Ulrike Gehring and 21 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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  11. [Analysis and Projection of the Burden of Chronic Respiratory Diseases Attributable to Smoking in China, 1990-2021].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Judith Garcia-AymerichISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain. Electronic address: judith.garcia@isglobal.org.
Martí de Las HerasISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.
Anne-Elie CarsinISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.
Simone AccordiniUnit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Istituti Biologici II, Verona, Italy.
Alvar AgustíMedicine Department, University of Barcelona, Barcelona, Spain; Respiratory Institute, Clinic Barcelona, Barcelona, Spain; FCRB-IDIBAPS, Barcelona, Spain; CIBERES, Madrid, Spain.
Dinh BuiAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Shyamali C DharmageAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
James W DoddAcademic Respiratory Unit, NIHR Bristol Biomedical Research Centre and Bristol Medical School, University of Bristol, Bristol, UK.
Ikenna EzeSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands.
Thorarinn GislasonDepartment of Sleep, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Raquel GranellMRC Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Medea ImbodenSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Carmen ÍñiguezCIBER Epidemiología y Salud Pública, Madrid, Spain; Department of Statistics and Operational Research, University of Valencia, Burjassot, Spain.
Ayoung JeongSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Sarah KochISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.
Gerard H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Bénédicte LeynaertUniversité Paris-Saclay, UVSQ, Université Paris-Sud, Inserm, CESP, Équipe d'Épidémiologie Respiratoire Intégrative, Villejuif, France.
Erik MelénDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Jennifer PerretAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Nicole Probst-HenschSwiss Tropical and Public Health Institute, Allschwil, Switzerland; University of Basel, Basel, Switzerland.
Loreto Santa-MarinaCIBER Epidemiología y Salud Pública, Madrid, Spain; Group of Environmental Epidemiology and Child Development, Biogipuzkoa Health Research Institute, San Sebastian, Spain; Department of Health of the Basque Government, San Sebastian, Spain.
Maties TorrentIB-SALUT, Àrea de Salut de Menorca, IdISBa, Maó, Spain.
Don VicendeseAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; School of Computing, Engineering and Mathematical Sciences, La Trobe University, Melbourne, VIC, Australia.
Judith M VonkGRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Maaike de VriesGRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
E Haydn WaltersAllergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Gang WangDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
Jadwiga A WedzichaNational Heart and Lung Institute, Imperial College London, London, UK.
Deborah JarvisNational Heart and Lung Institute, Imperial College London, London, UK.
Rosa FanerBiomedicine Department, University of Barcelona, Barcelona, Spain; FCRB-IDIBAPS, Barcelona, Spain; CIBERES, Madrid, Spain.

Funding

HSRD VA TPR 15-230Wellcome Trust
6 · The paper itself

Abstract

backgroundLung function is a key determinant of health, but current knowledge on lung function growth and decline over the life course is based on fragmented, potentially biased data. We aimed to empirically derive general population-based life course lung function trajectories, and to identify breakpoints and plateaus.

methodsWe created an accelerated cohort by pooling data from eight general population-based child and adult cohort studies from Europe and Australia. We included all participants with information on lung function, smoking status, BMI, and asthma diagnosis status from at least two visits. We used cross-classified three-level linear mixed models to derive sex-specific life course trajectories of FEV

findingsThe accelerated cohort included 30 438 participants born between 1901 and 2006 (15 703 [51·6%] female and 14 735 [48·4%] male; mean age 26 [SD 16] years), who provided a total of 87 666 observations (range 2-8 observations per participant). In female participants, FEV

interpretationIn both sexes, FEV

fundingEU Horizon 2020, Wellcome, European Respiratory Society, AstraZeneca, Chiesi, GSK, Menarini Group, and Sanofi.

Indexed as

AsthmaLungAdolescentAdultAgedAged, 80 and overAustraliaBayes TheoremChildChild, PreschoolCohort StudiesEuropeFemaleForced Expiratory VolumeHumansMale

Identifiers

PMID40383131
PMCPMC12209707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.