Evidence map›Paper›PMID 40383020›Full record

ArticleNuclear medicine and biology

Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [

Tutukhanim Balayeva, Ruth H Asch, Peng Wen Tan, William Mennie, Jie Tong, Baosheng Chen, Zhenwu Zhuang, Chao Zheng, MingQiang Zheng, Takuya Toyonaga and 1 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tutukhanim BalayevaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Faculty of Medicine, Eberhard Karls Universität Tübingen, Baden-Württemberg, Germany.
Ruth H AschDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Peng Wen TanDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
William MennieDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA.
Jie TongDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Baosheng ChenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Zhenwu ZhuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Department of Cardiovascular Medicine, Yale University, New Haven, CT, USA.
Chao ZhengDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
MingQiang ZhengDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Zhengxin CaiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. Electronic address: Jason.cai@yale.edu.

Funding

Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
SV2A PET in Spinal Cord Injury ImagingR01NS123183 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai · 2022 to 2026
$3.3M
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's diseaseRF1NS130069 · NINDS · YALE UNIVERSITY · PI CAI, ZHENGXIN, LAKE, EVELYN MR · 2022 to 2022
$2.5M
Development of Novel SV2A PET Agents for Early Detection of Alzheimers DiseaseR01AG058773 · NIA · YALE UNIVERSITY · PI CAI, ZHENGXIN · 2018 to 2020
$2.4M
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's diseaseR01NS130069 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai, Evelyn MR Lake · 2025 to 2026
$1.7M
NCATS NIH HHS KL2 TR001862NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG058773NINDS NIH HHS R01 NS123183NINDS NIH HHS R01 NS130069NINDS NIH HHS RF1 NS130069
6 · The paper itself

Abstract

purposeAlterations in synaptic vesicle glycoprotein 2A (SV2A) are linked to various neurodegenerative and neuropsychiatric disorders. Positron emission tomography (PET) imaging with radiotracers targeting SV2A, such as [

methodsAll rats received intravenous infusions of [

resultsWe observed a decline in [

conclusionWe were able to reliably evaluate the parent fractions of [

Indexed as

Chromatography, Thin LayerFluorine RadioisotopesAnimalsAutoradiographyBrainChromatography, High Pressure LiquidPositron-Emission TomographyPyridinesPyrrolidinesRatsFluorine RadioisotopesPyridinesPyrrolidinesSynVesT-1High-performance liquid chromatography (HPLC)Parent fractionPositron emission tomography (PET)Radiometabolite analysisSynaptic vesicle glycoprotein 2A (SV2A)Thin-layer chromatography (TLC)

Identifiers

PMID40383020
PMCPMC12228526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.