ArticleAutonomic neuroscience : basic & clinical2025
Mechanism of heat treatment on exercise pressor reflex in hindlimb ischemia-reperfusion: Does the temperature gradient matter?
Article in Autonomic neuroscience : basic & clinical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeTo examine the effect of heat treatment (HT) with two temperature gradients in skeletal muscle: 1.5 and 3 °C, on the exercise pressor reflex (EPR) responses following limb ischemia-reperfusion (IR). Specifically, the involvement role of the P2Xs (receptors of ATP) pathway in the muscle afferent neurons was accessed.
methodsAn experimental IR model was induced by 6 h of ischemia followed by 18 h of reperfusion in rats (IR rats). For HT groups, three HT sessions (muscle temperature increased by 1.5 or 3 °C) lasted for 30 mins each were applied. EPR responses were evoked by static muscle contraction (30s). Protein expression of P2X3 receptor in dorsal root ganglions (DRGs) was evaluated by western blot. In addition, a calcium imaging study was applied to detect calcium influx induced by activation of P2X3 in the isolated muscle DRG neurons of studied animal groups. Data are presented as mean ± standard deviation (M ± SD).
resultsThe mean arterial pressure (MAP) response to the static muscle contraction was significantly exaggerated in rats of IR 18 h (vs. sham, p < 0.01). The exaggerated BP response was attenuated with increasing Tm by 1.5 and 3 °C (vs. IR, p < 0.05). The expression of the P2X3 receptor was significantly enhanced in the DRGs of IR 18 h rats (vs. sham, p < 0.01). The upregulated P2X3 was suppressed in the DRGs of IR 18 h rats +HT of 1.5 °C and 3 °C (vs. IR, p < 0.05). In the isolated muscle afferent neurons, the Ca
conclusionIR injury leads to upregulation of EPR responses, and HT attenuates this effect. The P2X3 signaling pathway was involved in the beneficial regulatory effect of HT on EPR in IR. The temperature gradient did not play a role in the extent of BP and muscle afferent P2X pathway activity attenuation in the present study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.