Evidence map›Paper›PMID 40382786›Full record

ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2025

No advantage of fundoplication in paraesophageal hernia repair: a retrospective multicenter study.

Lene Østerballe, Eirik K Aahlin, Rasmus Goll, Mahdi Alamili, Per-Even Storli, Mads V Gran, Cecilie B Lassen, Palle B Miliam, Kim E Mortensen

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Gastropexy may reduce symptomatic recurrence in paraesophageal hernia repair: a Scandinavian retrospective multicenter study.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2026
    Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lene ØsterballeDepartment of Gastrointestinal Surgery, University Hospital of Northern Norway, St. Olavsgate 70, 9405 Harstad, Norway.
Eirik K AahlinInstitute of Clinical Medicine, UiT the Arctic University of Norway, Hansine Hansensvei 18, 9019 Tromsø, Norway.
Rasmus GollInstitute of Clinical Medicine, UiT the Arctic University of Norway, Hansine Hansensvei 18, 9019 Tromsø, Norway.
Mahdi AlamiliDepartment of Gastrointestinal Surgery, Hvidovre Hospital, Kettegårdsalle 36, 2650 Hvidovre, Copenhagen, Denmark.
Per-Even StorliDepartment of Gastrointestinal Surgery, St. Olavs Hospital, Trondheims University Hospital, Prinsesse Kristinas Gate 3, 7030 Trondheim, Norway.
Mads V GranDepartment of Gastrointestinal Surgery, St. Olavs Hospital, Trondheims University Hospital, Prinsesse Kristinas Gate 3, 7030 Trondheim, Norway.
Cecilie B LassenDepartment of Gastrointestinal Surgery, Hvidovre Hospital, Kettegårdsalle 36, 2650 Hvidovre, Copenhagen, Denmark.
Palle B MiliamDepartment of Gastrointestinal Surgery, Hvidovre Hospital, Kettegårdsalle 36, 2650 Hvidovre, Copenhagen, Denmark.
Kim E MortensenInstitute of Clinical Medicine, UiT the Arctic University of Norway, Hansine Hansensvei 18, 9019 Tromsø, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraesophageal hernia repair often includes both gastropexy and fundoplication. The fundoplication may cause persistent side effects, and the necessity of the procedure is uncertain. This study aimed to compare gastropexy with or without fundoplication. A retrospective multicenter study was conducted from three Scandinavian hospitals. Patients, with grade III-IV hiatal hernia, who had a laparoscopic repair with total hernia sack removal, closure of hiatus, gastropexy either with or without Nissen fundoplication were included. Outcomes were per- and postoperative complications, postoperative symptom control, and recurrence. A total of 320 patient cases were included in the study (72 patients with Nissen fundoplication and 248 patients without fundoplication). Baseline variables were comparable between the two groups. We found no difference in perioperative or postoperative events, reflux control or recurrence. Median operation time differed with 49 minutes (P < 0.001) in patients with fundoplication (Median: 108 minutes, interquartile range (IQR): 88-131 minutes) compared to patients without fundoplication (59 minutes, IQR = 46-78 minutes). We also found an increased risk for second repair in the fundoplication group (OR 4.3, 95% CI 1.4-13.3). This study shows no benefits of adding a Nissen fundoplication procedure to anterior gastropexy for paraesophageal hernia repair. It was not superior compared to gastropexy alone in terms of postoperative reflux control or preventing recurrence. In contrast, the fundoplication was associated with a four-fold increase of second repair, but the study design limits firm conclusions on this matter.

Indexed as

FundoplicationGastropexyHernia, HiatalHerniorrhaphyAgedFemaleGastroesophageal RefluxHumansLaparoscopyMaleMiddle AgedOperative TimePostoperative ComplicationsRecurrenceReoperationRetrospective Studiesanti-reflux surgeryforegut surgerylarge hiatal hernianissen fundoplicationparaesophageal hernia

Identifiers

PMID40382786
PMCPMC12085915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.