Evidence map›Paper›PMID 40382756›Full record

ArticleSurgery today2025

Early postnatal neonatal surgery is associated with a low risk of surgical site infections.

Yuhki Koike, Koki Higashi, Yuki Sato, Shinji Yamashita, Yuka Nagano, Takahito Kitajima, Tabanobu Shimura, Kohei Matsushita, Yoshiki Okita, Yoshinaga Okugawa and 2 more

Abstract read
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Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuhki KoikeDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan. koikyon@med.mie-u.ac.jp.
Koki HigashiDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Yuki SatoDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Shinji YamashitaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Yuka NaganoDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Takahito KitajimaDepartment of Cancer Genome, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Tabanobu ShimuraDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Kohei MatsushitaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Yoshiki OkitaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.
Yoshinaga OkugawaDepartment of Cancer Genome, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Toru OguraClinical Research Support Center, Mie University Hospital, Tsu, Mie, Japan.
Yuji ToiyamaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu, Mie, 514-8507, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite the recognition of the negative effects of surgical site infection (SSI), data on neonatal surgery are limited. This study investigated the risk factors for SSI development in the neonatal period.

methodsNeonatal surgeries performed by pediatric surgeons at the Mie University Hospital between 2007 and 2023 were retrospectively reviewed. The correlation between age at surgery and the presence of SSI was analyzed, and the optimal cutoff value for age at surgery was determined with respect to SSI. The predictors of SSI were analyzed using a logistic regression analysis.

resultsAmong 272 neonatal surgeries, SSI was identified in 19 patients (7.0%). Patients with SSI were significantly older than those without SSI (P = 0.003), and the optimal cut-off value was age > 3 days. The incidence rate of SSI was 2.05% in the ≤ 3-day-old group and 12.7% in the > 3 day-old group (P < 0.001). A multivariate analysis revealed that intestinal perforation, preoperative elevated C-reactive protein (CRP) level, and surgery at > 3 days old were independent predictors of SSI.

conclusionIntestinal perforation, preoperative elevated CRP, and surgery after 3 days old are associated with an increased SSI risk in neonatal surgery.

Indexed as

Surgical Procedures, OperativeSurgical Wound InfectionAge FactorsBiomarkersC-Reactive ProteinFemaleHumansIncidenceInfant, NewbornIntestinal PerforationMaleRetrospective StudiesRisk FactorsTime FactorsBiomarkersC-Reactive ProteinPediatric surgeryRisk factorSurgical site infection

Identifiers

PMID40382756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.