Evidence map›Paper›PMID 40382653›Full record

ArticleEuropean journal of medical research2025

Rétrograde venous perfusion (RVP) for intraçtable venous leg ulcers: a retrospective analysis.

Alaa Sharabi, Mohammed Abd-Eltawab, Sherif A Sharabi, Mai A Elkalla, Yossef N Abdelbaky, Mohamed A Abou Yossef, Ahmed Mousa

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Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Alaa SharabiDepartment of Vascular Surgery and Endovascular Therapy, Al-Hussein University Hospital, Faculty of Medicine for Males, Al-Azhar University, Darrasa, Cairo, 11633, Egypt.
Mohammed Abd-EltawabDepartment of Vascular Surgery and Endovascular Therapy, Faculty of Medicine, Assiut University Hospital, Al-Azhar University, Assiut Branch, Assiut, Egypt.
Sherif A SharabiDepartment of Vascular Surgery and Endovascular Therapy, Al-Hussein University Hospital, Faculty of Medicine for Males, Al-Azhar University, Darrasa, Cairo, 11633, Egypt.
Mai A ElkallaFaculty of Medicine, Bader University Hospital, Helwan University, Helwan District, Cairo, Egypt.
Yossef N AbdelbakyFaculty of Medicine, Bader University Hospital, Helwan University, Helwan District, Cairo, Egypt.
Mohamed A Abou YossefDepartment of Vascular Surgery and Endovascular Therapy, Al-Hussein University Hospital, Faculty of Medicine for Males, Al-Azhar University, Darrasa, Cairo, 11633, Egypt.
Ahmed MousaDepartment of Vascular Surgery and Endovascular Therapy, Al-Hussein University Hospital, Faculty of Medicine for Males, Al-Azhar University, Darrasa, Cairo, 11633, Egypt. asgbi@azhar.edu.eg.ORCID http://orcid.org/0000-0002-0840-4080

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetrograde venous perfusion (RVP) is a minimally invasive procedure in which the limb circulation is isolated by the application of a proximal limb tourniquet, followed by the administration of specific medications through a distal limb vein. This allows these drugs to pass in the reverse direction to reach the ulcerated area of the affected limb. The aim of this study was to evaluate the safety, feasibility, and efficacy of RVP, for the management of long-standing intractable chronic venous leg ulcers (CVLUs).

methodsA 4-year retrospective study took place from January 2021 to January 2025. All patients who underwent the RVP technique were included in the study. These patients had chronic, intractable, long-standing, nonhealing, venous leg ulcers. They were classified into two groups. Group I included those who underwent RVP (treated group). However, group II was treated with standard compression therapy (control group). A paired-samples t test was performed to compare the studied groups. Kaplan-Meier survival analysis was performed for patients who were free from ulcer recurrence or nonhealing after the RVP technique.

resultsDuring the 4-year study period, 384 patients were retrospectively analyzed. A total of 75% (n = 288) of the participants were females, and 25% were males (n = 96). The median age was 37.26 ± 4.2 years. Ulcers ranged between 30cm

conclusionsCompared with the standard compression technique, RVP therapy may be considered an effective and feasible technique for treating intractable venous leg ulcers. It offers shorter periods of therapy with a high success rate in reducing ulcer size/complete wound healing within a short period of time. This therapeutic option may provide essential evidence to reduce the negative social and economic impact on affected populations.

Indexed as

PerfusionVaricose UlcerAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeWound HealingChronic venous leg ulcersHealing of chronic venous leg ulcersIntractable venous leg ulcersLong-standing venous leg ulcersNonhealing venous leg ulcersResistant venous leg ulcersRetrograde venous perfusion (RVP) procedure

Identifiers

PMID40382653
PMCPMC12084939

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