Evidence map›Paper›PMID 40382641›Full record

ReviewJournal of nanobiotechnology2025

Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy.

Hao Zheng, Yiquan Chen, Wei Luo, Shiqi Han, Mengjuan Sun, Min Lin, Chenghan Wu, Lili Gao, Tian Xie, Na Kong

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Bone reports · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Emerging nanomedicine for liver diseases treatment.Journal of nanobiotechnology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao ZhengDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian, China.
Yiquan ChenLiangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 311121, Zhejiang, China.
Wei LuoCollege of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Shiqi HanCollege of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Mengjuan SunCollege of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Min LinDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian, China.
Chenghan WuDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian, China.
Lili GaoDepartment of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian, China. Gaolilidexingfu@163.com.
Tian XieCollege of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China. tianxie@hznu.edu.cn.
Na KongLiangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 311121, Zhejiang, China. kongna@zju.edu.cn.

Funding

the National Natural Science Foundation of China No. 82122076
6 · The paper itself

Abstract

Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. The active ingredients of traditional Chinese medicine (TCM) demonstrate a variety of anti-tumor activities and mechanisms, including the modulation of immune cell functions and inhibiting tumor-related suppressive factors, thereby potentially enhancing anti-tumor immune responses. Furthermore, nano-delivery systems function as efficient carriers to enhance the bioavailability and targeted delivery of TCM active ingredients, augmenting therapeutic efficacy. This review comprehensively analyzes the impact of TCM active ingredients on the immune system and explores the synergistic application of nano-delivery systems in combination with TCM active ingredients for enhancing tumor immunotherapy.

Indexed as

Drug Delivery SystemsDrugs, Chinese HerbalImmunotherapyMedicine, Chinese TraditionalNanoparticle Drug Delivery SystemNeoplasmsAnimalsHumansNanoparticlesDrugs, Chinese HerbalNanoparticle Drug Delivery SystemActive ingredientsDrug deliveryNanocarriersTCMTumor immunotherapy

Identifiers

PMID40382641
PMCPMC12085060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.