Evidence map›Paper›PMID 40382638›Full record

ArticleCell communication and signaling : CCS2025

Alk

G Wolfstetter, T Masudi, E Uçkun, J Y Zhu, M Yi, V Anthonydhason, J Guan, H Sonnenberg, Z Han, R H Palmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Construction and Expression Analysis of themicroPublication biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

G WolfstetterDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden. georg.wolfstetter@su.se.ORCID http://orcid.org/0000-0001-8763-1419
T MasudiDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-7406-9084
E UçkunDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-7745-8277
J Y ZhuCenter for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID http://orcid.org/0000-0002-4517-101X
M YiDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.
V AnthonydhasonDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-6982-4030
J GuanDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.
H SonnenbergDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden.
Z HanCenter for Precision Disease Modeling, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.ORCID http://orcid.org/0000-0002-5177-7798
R H PalmerDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, 41390, Gothenburg, Sweden. ruth.palmer@gu.se.ORCID http://orcid.org/0000-0002-2735-8470

Funding

Screen and functional validation of Pediatric Cardiomyopathy genetic variants in DrosophilaR01HD111480 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHE HAN · 2023 to 2026
$2.6M
Functional characterization of genes and genetic variants associated with hypoplastic heart syndrome in DrosophilaR01HL180768 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHE HAN · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL180768NICHD NIH HHS R01 HD111480
6 · The paper itself

Abstract

Anaplastic lymphoma kinase (Alk) signaling is important in a variety of biological contexts such as cell type specification, regulation of metabolic and endocrine programs, behavior, and cancer. In this work, we generated a Tango GPCR assay-based, dimerization-sensitive Alk activity reporter (Alk

Indexed as

Anaplastic Lymphoma KinaseDrosophila melanogasterDrosophila ProteinsHeartSignal TransductionAnimalsLarvaMyocytes, CardiacAnaplastic Lymphoma KinaseDrosophila Proteinsjeb protein, DrosophilaCardiac arrythmiaCardiomyocyteCRISPR/Cas9Jelly bellyTango RTK activity assayWing hearts

Identifiers

PMID40382638
PMCPMC12085853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.