ArticleJournal of orthopaedic surgery and research2025
Global burden of vertebral fractures from 1990 to 2021 and projections for the next three decades.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the risk of vertebral fracture in patients with osteoporosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Proportions of fall-related and insufficiency-related vertebral fractures among hospitalized older patients.Archives of osteoporosis · 2026Article
- Acute-phase rehabilitation for osteoporotic vertebral fractures: current evidence from scoping review.Asian spine journal · 2026Article
- Global, regional, and national burden of vertebral fractures among women from 1990 to 2021: a systematic analysis based on the global burden of disease study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Intermediate screw placement improves initial radiographic alignment but not clinical outcomes following long-segment fixation for thoracolumbar fractures.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Developing and validating a combined model with CT-based paraspinal muscle radiomics and clinical features to predict residual low back pain after percutaneous kyphoplasty.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Multidisciplinary management of acute osteoporotic vertebral fracture: results of a national Delphi consensus.Archives of osteoporosis · 2026Article
- Epidemiology of Traumatic Spinal Fractures at Ibra Hospital, Oman: A Retrospective Study With Regional Comparisons.Cureus · 2026Article
- Muscle mass, not fat mass, predicts vertebral fracture risk: Vietnam osteoporosis study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Living with an osteoporotic vertebral compression fracture: a qualitative exploration of patient and healthcare professional perspectives.Archives of osteoporosis · 2026Article
- SPINE20 recommendations 2025: Sustainable spine care for all.Brain & spine · 2026Article
- From Detection to Decision: T-Score-Guided Use of STIR MRI After CT in Vertebral Fractures.Diagnostics (Basel, Switzerland) · 2025Article
- Epidemiology and Future Burden of Vertebral Fractures: Insights from the Global Burden of Disease 1990-2021.Healthcare (Basel, Switzerland) · 2025Article
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8 authors.
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Abstract
backgroundVertebral fractures are linked to significant disability and mortality risks. Yet, existing studies on their global burden are outdated and lack predictive foresight.
methodsPublic data from the 2021 GBD study were analyzed to assess the global burden and epidemiological trends of vertebral fractures. The annual percentage change (EAPC) was calculated to represent temporal trends from 1990 to 2021. Machine learning was used to predict the global burden of vertebral fractures over the next 30 years.
resultsFrom 1990 to 2021, the global burden of vertebral fractures significantly decreased. The age-standardized incidence rates (ASIR) showed the largest decline in Eastern Sub-Saharan Africa (EAPC: -1.5; 95% CI: -2.0 to -1.0), while North Africa and the Middle East were the only regions to report an increase (EAPC: 0.3; 95% CI: 0.1 to 0.5). For age-standardized prevalence rates (ASPR), High-income Asia Pacific saw the steepest decline (EAPC: -1.4; 95% CI: -1.5 to -1.2), while the Caribbean experienced the largest increase (EAPC: 0.8; 95% CI: 0.4 to 1.3). Similarly, in terms of age-standardized years lived with disability rates (ASYR), the most substantial reduction occurred in High-income Asia Pacific (EAPC: -1.4; 95% CI: -1.5 to -1.3), with the Caribbean again showing the greatest rise (EAPC: 0.8; 95% CI: 0.3 to 1.2). Males generally exhibited higher age-standardized rates (ASRs) than females, although females aged 65-70 years old surpassed males. Predictive models suggest continued declines in global ASIR, ASPR, and ASYR by 2050.
conclusionsOur study shows a steady reduction in the global burden of vertebral fractures from 1990 to 2021. Nevertheless, disparities remain across regions, with a positive correlation between ASRs with SDI.
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