ArticleBMC plant biology2025
A three-way transcriptomic crosstalk interaction in a biocontrol agent (Bacillus velezensis), a fungal pathogen (Colletotrichum gloeosporioides), and a walnut host (Juglans regia L.).
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Field Root-Associated Microbiome Characteristics ofJournal of fungi (Basel, Switzerland) · 2026Article
- Molecular Identification and RNA-Based Management of Fungal Plant Pathogens: From PCR to CRISPR/Cas9.International journal of molecular sciences · 2026Review
- EngineeringAIMS microbiology · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
Walnut anthracnose, caused by Colletotrichum gloeosporioides, is a globally significant disease. Bacillus velezensis demonstrates strong inhibitory effects against C. gloeosporioides. Current research primarily focuses on interactions between two species, leaving the molecular mechanisms of three-way interactions among walnut, pathogen, and biocontrol agent unexplored. To elucidate the molecular mechanisms in the "Walnut-C. gloeosporioides-B. velezensis" system, we employed three-way RNA-Seq to obtain transcriptome data for each species. We identified 111,674, 799, and 79 differentially expressed genes (DEGs) in walnut, C. gloeosporioides, and B. velezensis respectively. By integrating WGCNA and PPI network analyses, we discovered 3 key modules and 10 hub genes in C. gloeosporioides, and 2 key modules and 2 hub genes in B. velezensis. Functional enrichment analyses (GO and KEGG) revealed that walnut DEGs were enriched in secondary metabolism, disease-resistance proteins, plant hormone signal transduction, and pathogenesis-related proteins; C. gloeosporioides DEGs were associated with binding, antigen processing and presentation, and regulation of actin cytoskeleton; B. velezensis DEGs were linked to transmembrane transport, amino acid biosynthesis, carbon metabolism, and TCA cycle. These results demonstrate that the transcriptional responses of the three species mutually influence each other within the three-way system. This study addresses knowledge gaps in the biocontrol-pathogen-host interaction and provides a theoretical foundation for developing environmentally sustainable strategies to control walnut anthracnose.
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