ArticleBMC cardiovascular disorders2025
Risk of acute ischemic stroke with early versus late initiation of mechanical circulatory support in hospitalizations with acute myocardial infarction complicated by cardiogenic shock: a propensity-matched analysis.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Timing of IABP initiation and its impact on outcomes in acute myocardial infarction with cardiogenic shock: insights from a bi-center retrospective study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Observational
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10 authors.
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Abstract
backgroundMechanical circulatory support (MCS) devices have been widely used for managing acute myocardial infarction complicated by cardiogenic shock (AMI-CS). However, their use additionally elevates acute ischemic stroke (AIS) risk. There is insufficient data on the risk of AIS associated with early versus late initiation of MCS in AMI-CS cases. Therefore, this study aimed to assess the timing of MCS initiation associated with the risk of AIS in hospitalizations with AMI-CS.
methodsA retrospective data analysis of the National Inpatient Sample (January 2016-December 2020) identified AMI-CS hospitalizations: categorized into early MCS initiation (< 48 h) and late MCS initiation (> 48 h). The primary outcome was AIS; the secondary outcomes included in-hospital mortality, acute kidney injury (AKI), cardiac arrest, major bleeding, and blood transfusion. The outcomes were compared using logistic multivariate regression and 1:1 propensity score matching analyses between the groups.
resultsAmong 78,405 weighted hospitalizations with AMI-CS receiving MCS, 82.77% (n = 64,895) and 17.23% (n = 13,510) underwent early and late MCS initiation, respectively. Hospitalizations with late MCS initiation had higher risks of AIS (adjusted odds ratio [aOR], 1.46; 95%confidence interval [CI], 1.19-1.79; p < 0.001), AKI (aOR, 1.41; 95%CI, 1.27-1.55; p < 0.001), and major bleeding (aOR, 1.12; 95%CI, 1.01-1.23; p = 0.028). After propensity score matching, late MCS initiation remained associated with increased risks of AIS (aOR, 1.39; 95%CI, 1.08-1.78; p = 0.010), AKI (aOR, 1.37; 95%CI, 1.23-1.53; p < 0.001), and major bleeding (aOR, 1.14; 95%CI, 1.02-1.28; p = 0.027).
conclusionsLate initiation of MCS was associated with increased risks of AIS, AKI, and major bleeding.
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