Evidence map›Paper›PMID 40382399›Full record

ArticleScientific reports2025

Aptamer-enhanced ultrasensitive electrochemical detection of HER-2 in breast cancer diagnosis using ZnO tetrapod-K

Reema Rawat, Souradeep Roy, Tapas Goswami, Fatemeh Sadat Mirsafi, Mustafa Ismael, Till Leissner, Yogendra Kumar Mishra, James McLaughlin, Krishna Kant, Ashish Mathur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Reema RawatDepartment of Allied Health Sciences, School of Health Sciences and Technology, UPES, Dehradun, India.
Souradeep RoyDepartment of Allied Health Sciences, School of Health Sciences and Technology, UPES, Dehradun, India.
Tapas GoswamiDepartment of Chemistry, School of Advanced Engineering, UPES, Dehradun, India.
Fatemeh Sadat MirsafiMads Clausen Institute, University of Southern Denmark, NanoSYD, Sønderborg, Denmark.
Mustafa IsmaelMiddle Technical University, Al-Za'faraniyah, St. 54, Baghdad, Iraq.
Till LeissnerMads Clausen Institute, University of Southern Denmark, NanoSYD, Sønderborg, Denmark.
Yogendra Kumar MishraMads Clausen Institute, University of Southern Denmark, NanoSYD, Sønderborg, Denmark.
James McLaughlinSchool of Engineering, Ulster University, Belfast, UK.
Krishna KantCINBIO, Universidade de Vigo, Campus Universitario As Lagoas Marcosende, Vigo, 36310, Spain. Krishna.kant@uvigo.gal.
Ashish MathurCentre for Interdisciplinary Research and Innovation (CIDRI), UPES, Dehradun, India. ashish.mathur@ddn.upes.ac.in.

Funding

Indo-ASEAN grant CRD/2021/000472UPES SEED infrastructure grant UPES/R&D-SEED-INFRA/11032022/01
6 · The paper itself

Abstract

Breast cancer continues to be a severe global health issue, emphasizing the critical need for accurate and timely detection and screening of large numbers of patients. This ailment places an enormous strain on healthcare resources and poses severe mortality risks for women globally if not addressed promptly. Conventional diagnostic techniques face obstacles such as expensive apparatus, intricate procedures, and long duration in stratification. Therefore, the development of point-of-care (PoC) devices that enable early detection of breast cancer is of utmost importance. This research article focuses on the development of an electrochemical based aptasensor for the detection of Human Epidermal Growth Factor Receptor 2 (HER-2) using the novel nanohybrid substrate material, which consists of a 3D Zinc Oxide Tetrapods (ZnOT) and Potassium Perylene Tetra Carboxylate (K

Indexed as

Aptamers, NucleotideBiosensing TechniquesBreast NeoplasmsElectrochemical TechniquesErb-b2 Receptor Tyrosine KinasesPeryleneZinc OxideFemaleHumansLimit of DetectionAptamers, NucleotideERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesPeryleneZinc OxideAffordable healthcareBreast cancerEarly detectionElectrochemical biosensorHER-2ZnOT-K4PTC nanohybrids

Identifiers

PMID40382399
PMCPMC12085555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.