Evidence map›Paper›PMID 40382389›Full record

ArticleScientific data2025

Transcriptome of Taenia solium during in vitro cyst activation and initial growth into the tapeworm stage.

David Castaneda-Carpio, Renzo Gutierrez-Loli, Jose Maravi-Jaime, Segundo W Del Aguila, Valeria Villar-Davila, Luz M Moyano, Rafael Tapia-Limonchi, Stella M Chenet, Cristina Guerra-Giraldez

Abstract readDataset
In one paragraph

Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David Castaneda-CarpioLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru. david.castaneda.c@upch.pe.
Renzo Gutierrez-LoliLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.ORCID http://orcid.org/0000-0001-6466-5288
Jose Maravi-JaimeLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Segundo W Del AguilaLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Valeria Villar-DavilaLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.
Luz M MoyanoCentro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, San Martín de Porres, Peru.
Rafael Tapia-LimonchiInstituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru.
Stella M ChenetInstituto de Investigación de Enfermedades Tropicales, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru.
Cristina Guerra-GiraldezLaboratorio de Proliferación Celular y Regeneración, Facultad de Ciencias e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru. cristina.guerra@upch.pe.ORCID http://orcid.org/0000-0002-9287-9838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cestode Taenia solium develops as a tapeworm solely in the human intestine, starting from a larva (cyst). Upon maturing, it produces hundreds of thousands of infectious eggs. When ingested by pigs or humans, the eggs develop as cysts that lodge in various tissues, including the brain, leading to neurocysticercosis. Despite advances in understanding cestode biology through genomic and transcriptomic studies, particularly in model organisms, much remains unknown about the activation of T. solium cysts in the human digestive tract and the events that drive the development into adult worms-the stage responsible for dispersing the parasite. We present a transcriptome generated by Next Generation Sequencing from T. solium cysts activated in culture and collected at three different in vitro growth phases, defined by their morphology. Differentially expressed genes and biological processes relevant to activation and growth can be explored with the dataset. The information is valuable for identifying genes that regulate the molecular, metabolic, and cellular events leading to parasite maturation or elements driving its transmission.

Indexed as

Taenia soliumTranscriptomeAnimalsHumansSwine

Identifiers

PMID40382389
PMCPMC12085659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.