Evidence map›Paper›PMID 40382338›Full record

ArticleNature communications2025

A midbrain circuit mechanism for noise-induced negative valence coding.

Siyao Zhou, Yuebin Zhu, Ana Du, Shuai Niu, Yonglan Du, Yan Yang, Wenqiang Chen, Siyu Du, Li Sun, Yijun Liu and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siyao Zhou *Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yuebin Zhu *Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Ana Du *Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Shuai NiuDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yonglan DuDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Yan YangDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Wenqiang ChenSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-1289-7068
Siyu DuDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Li SunDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0001-8009-1296
Yijun LiuDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Hangjun WuDepartment of Pathology of Sir Run Run Shaw Hospital; Center of Cryo-Electron Microscopy, Zhejiang University, Hangzhou, China.
Huifang LouDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.
Xiao-Ming LiNHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-8617-1702
Shumin DuanDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-0466-1821
Hongbin YangDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China. hongbinyang@zju.edu.cn.ORCID http://orcid.org/0000-0001-8574-1542

Funding

Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LR24C090001
6 · The paper itself

Abstract

Unpleasant sounds elicit a range of negative emotional reactions, yet the underlying neural mechanisms remain largely unknown. Here we show that glutamatergic neurons in the central inferior colliculus (CIC

Indexed as

EmotionsInferior ColliculiMesencephalonNoiseVentral Tegmental AreaAcoustic StimulationAnimalsAuditory PathwaysAuditory PerceptionDopamineFemaleGABAergic NeuronsGeniculate BodiesMaleMiceMice, Inbred C57BLDopamine

Identifiers

PMID40382338
PMCPMC12085634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.