ArticleTranslational psychiatry2025
Stellate ganglion block diminishes consolidation of conditioned fear memory in mice by inhibiting the locus coeruleus to the basolateral amygdala neural circuit.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect of stellate ganglion block on perioperative psychological symptoms and recovery after total hip arthroplasty for osteonecrosis of the femoral head in non-elderly patients: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Effect of preoperative ultrasound-guided stellate ganglion block on pain thresholds and postoperative nausea and vomiting in gynecological laparoscopy: a randomised clinical trial.BMC anesthesiology · 2026Trial
- Effect of high-frequency stellate ganglion block on sleep and affective symptoms in insomnia disorder: a prospective pilot study.BMC neurology · 2026Trial
- Preoperative Stellate Ganglion Block for Postoperative Sore Throat in Patients Undergoing Double-Lumen Endotracheal Intubation: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- The Stellate Ganglion Block for PTSD: A Retrospective Clinical Case Series.International journal of environmental research and public health · 2026Article
- Advances in the clinical application of stellate ganglion block for non-pain indications.Frontiers in medicine · 2026Review
- Application of stellate ganglion modulation in mental disorders and the future prospects of physical therapies.Fundamental research · 2026Review
- Editorial: New insights into stellate ganglion blockade in basic and clinical studies.Frontiers in neuroscience · 2026Article
- Effect of stellate ganglion block on the prevention of posttraumatic stress disorder in patients undergoing emergency ocular trauma surgery: protocol for a randomized, double-blind, placebo-controlled trial.Frontiers in medicine · 2025Article
- Effectiveness and safety of ultrasound-guided stellate ganglion block in C57BL/6 mice.Frontiers in medicine · 2025Article
- Ultrasound-Guided Stellate Ganglion Block with Cervicotemporal Myofascial Trigger Point Acupuncture for Insomnia with Comorbid Anxiety and Depression: A Retrospective Observational Study.Nature and science of sleep · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Posttraumatic stress disorder (PTSD) is a devastating, prevalent psychological disorder characterized by excessive fear memory because of exposure to severe trauma. Stellate ganglion block (SGB) is traditionally used as a clinical treatment for pain but has been regarded as an innovative therapy for PTSD in recent reports. However, the mechanisms underlying the effect of SGB on PTSD remain unknown. Here, we established a fear conditioning model, which is considered a representative model of traumatic memory, and evaluated the effect of SGB on conditioned fear memory. We found that SGB reduced conditioned fear memory in mice in conjunction with the hypoactivity of locus coeruleus (LC) noradrenergic and basolateral amygdala (BLA) glutamatergic neurons. The norepinephrine concentration in the BLA decreased after SGB. Moreover, conditioned fear memory was re-enforced when the LC NE (LC
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