ArticleMethods in enzymology2025
Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis.
Article in Methods in enzymology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026Review
- Therapeutic regulation of gut microbiota in gastric cancer: mechanisms, strategies, and clinical prospects.Frontiers in microbiology · 2026Review
- Pathogenicity ofWorld journal of clinical oncology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Helicobacter pylori is a pathogen of the human stomach that infects half of the world's population. The chronicity of the infection is a major risk factor for the development of gastric cancer. Multiple parameters, including the heterogenicity of the virulence factors, the environmental parameters, or the intensity of the host responses, regulate the evolution of the disease. Thus, we have reported that the dysregulation of the polyamine pathway in the infected gastric mucosa represents a major component of the inflammation and the risk for neoplastic transformation. Using different animal models and gastric organoids, we recently highlighted the critical role of spermine oxidase-derived acrolein in the pathogenesis of H. pylori infection and the progression to carcinoma. Herein, we describe the experimental procedures that have been used, from the culture of the bacteria to the various models of infection in vivo and in vitro, and the assessment of acrolein generation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.