Evidence map›Paper›PMID 40381917›Full record

ArticleCellular and molecular gastroenterology and hepatology2025

Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification.

Elizabeth Y Flores, Aditya Mithal, Pushpinder Bawa, Feiya Wang, Andrew D'Amico, Aoife K O'Connell, Hans P Gertje, Anna E Tseng, Nicholas A Crossland, Yuriy Alekseyev and 1 more

Abstract read
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth Y FloresCenter for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Aditya MithalDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Center for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
Pushpinder BawaCenter for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
Feiya WangCenter for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
Andrew D'AmicoCenter for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
Aoife K O'ConnellNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Hans P GertjeNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Anna E TsengNational Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Nicholas A CrosslandDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts; National Emerging Infectious Diseases Laboratories (NEIDL), Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Yuriy AlekseyevDepartment of Pathology and Laboratory Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.
Gustavo MostoslavskyCenter for Regenerative Medicine (CReM), Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts; Department of Medicine, Section of Gastroenterology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts; Department of Virology, Immunology, and Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts. Electronic address: gmostosl@bu.edu.

Funding

NRSA Training CoreTL1TR001410 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2015 to 2024
$4.3M
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL75N92020C00005 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI N/A, N/A · 2021 to 2024
$2.6M
Dissecting the mechanisms of intestinal epithelial injury by Ebola virus using iPSC-derived intestinal organoidsR21AI167369 · NIAID · BOSTON MEDICAL CENTER · PI MOSTOSLAVSKY, GUSTAVO, MUHLBERGER, ELKE C · 2022 to 2023
$486k
Vectra Polaris Quantitative Pathology Imaging SystemS10OD030269 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2021 to 2021
$402k
Ventana Discovery Ultra Research Autostainer: an Ex+ Core serviceS10OD026983 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CROSSLAND, NICHOLAS ALEXANDER · 2019 to 2019
$207k
An iPSC-derived human organoid based model of intestinal filovirus infectionF31AI183803 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FLORES, ELIZABETH YVONNE · 2024 to 2024
$49k
NCATS NIH HHS TL1 TR001410NHLBI NIH HHS 75N92020C00005NIAID NIH HHS F31 AI183803NIAID NIH HHS R21 AI167369NIH HHS S10 OD026983NIH HHS S10 OD030269
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40381917
PMCPMC12365535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.