Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington's disease: a [

Liesbeth Everix, Franziska Zajicek, Annemie Van Eetveldt, Longbin Liu, Jonathan Bard, Steven Staelens, Daniele Bertoglio

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in NeuroImage. Clinical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liesbeth EverixMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium; µNeuro Center for Excellence, University of Antwerp, Antwerp, Belgium.

Franziska ZajicekMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium; µNeuro Center for Excellence, University of Antwerp, Antwerp, Belgium.

Annemie Van EetveldtMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium; µNeuro Center for Excellence, University of Antwerp, Antwerp, Belgium.

Longbin LiuCHDI Management, Inc., the Company that Manages the Scientific Activities of CHDI Foundation, Inc. Princeton, NJ, USA.

Jonathan BardCHDI Management, Inc., the Company that Manages the Scientific Activities of CHDI Foundation, Inc. Princeton, NJ, USA.

Steven StaelensMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium; µNeuro Center for Excellence, University of Antwerp, Antwerp, Belgium.

Daniele BertoglioMolecular Imaging Center Antwerp (MICA), University of Antwerp, Wilrijk, Belgium; µNeuro Center for Excellence, University of Antwerp, Antwerp, Belgium; Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium. Electronic address: daniele.bertoglio@uantwerpen.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is a neurodegenerative disorder characterized by involuntary movements, cognitive decline and psychiatric problems. HD has been associated with synaptic dysfunction and loss of the synaptic vesicle protein 2A (SV2A). SV2A can readily be quantified via positron emission tomography (PET) using the selective and high affinity SV2A radiotracer [

Indexed as

BrainHuntington DiseaseMembrane GlycoproteinsNerve Tissue ProteinsSynapsesAnimalsDisease Models, AnimalFemaleFluorine RadioisotopesMaleMiceMice, Inbred C57BLMice, TransgenicPositron-Emission TomographyPyridinesPyrrolidinesFluorine RadioisotopesMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinesSv2a protein, mouseSynVesT-1Huntington’s diseaseMouse modelPositron emission tomographySynapseSynaptic densitySynaptic vesicle protein 2A

Identifiers

PMID40381377

DOI10.1016/j.nicl.2025.103800

PMCPMC12143836

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.