ArticleOncology and therapy2025
A Cost-Effectiveness Analysis for Avelumab as a First-Line Maintenance Treatment of Advanced Urothelial Carcinoma in the Netherlands.
Article in Oncology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdvanced or metastatic urothelial carcinoma (UC) is an incurable disease with a high disease burden and a poor prognosis. Avelumab as first-line (1L) maintenance treatment is an innovative therapy option for patients with advanced or metastatic UC that has not progressed after 4-6 cycles of 1L platinum-based chemotherapy. This study aimed to assess the cost-effectiveness of avelumab maintenance treatment plus best supportive care (BSC) versus BSC alone from a Dutch societal perspective.
methodsA partitioned survival model was developed incorporating JAVELIN Bladder 100 trial data to inform overall and progression-free survival, adverse events incidence, and health-state utilities. Costs for drugs, healthcare resource use, adverse events, and indirect costs were obtained from national databases, the Dutch costing manual, and published literature. Assumptions were validated by clinical experts. An incremental cost-effectiveness ratio (ICER) was determined using lifetime incremental costs and quality-adjusted life years (QALY).
resultsAvelumab 1L maintenance treatment plus BSC was estimated to have €48,186 discounted incremental costs and 0.63 discounted incremental QALYs versus BSC alone, leading to a base-case ICER of €76,450, supported by consistent scenario and sensitivity analyses.
conclusionAvelumab 1L maintenance treatment is likely to be a cost-effective treatment in advanced or metastatic urothelial carcinoma in the Netherlands.
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