ArticleRice (New York, N.Y.)2025
Exploring FKBP12's Role in Enhancing Drought Tolerance in Rice.
Article in Rice (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- γ-Aminobutyric Acid (GABA) enhances heat tolerance in rice via integrated antioxidant defense, metabolic homeostasis and heat shock response.BMC plant biology · 2026Article
- Hormone priming and metabolic engineering of phytohormone crosstalk in rice under combined biotic and abiotic stresses: a multi-omics perspective for climate-resilient crop development.Frontiers in plant science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Rice, as the largest consumer of global freshwater resources, faces significant challenges due to increasing drought conditions exacerbated by climate change. In this study, we explore the critical role of FKBP12, a molecular chaperone protein, in modulating drought tolerance in rice. Utilizing a T-DNA insertional mutant (fkbp12) and FKBP12-overexpressing lines, we investigated the gene's influence on rice under various drought conditions. Our results revealed that the fkbp12 mutant exhibited significantly enhanced drought tolerance compared to the wild type, evidenced by improved water retention, reduced cellular damage, and an upregulated expression of key drought-responsive genes such as OsNCED3, OsSNAC1, and OsDREB2A. This suggests a compensatory upregulation of abscisic acid (ABA)-mediated pathways, enhancing the plant's ability to cope with water deficit. Conversely, overexpression of FKBP12 resulted in increased sensitivity to drought, likely due to disruption in stress signaling and reactive oxygen species (ROS) scavenging mechanisms. Additionally, we observed an impact on seed development, where the fkbp12 mutant presented smaller seed sizes, indicating a potential trade-off between growth and stress tolerance. This comprehensive analysis not only highlights the diverse roles of FKBP12 in drought stress response but also its implications for rice yield and seed development, providing valuable insights for breeding more resilient rice varieties in the face of escalating climate challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.