Evidence map›Paper›PMID 40381105›Full record

ArticleImmunologic research2025

Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus.

Xiaoning Chen, Bing Shen, Weijie Lin, Ziqi Xiong, Bohao Yang, Hanxi Luo, Zhiwei Zong, Jie Chen, Ayibaota Bahabayi, Chen Liu

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Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoning Chen *Department of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.
Bing Shen *Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Weijie Lin *School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Ziqi XiongDepartment of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.
Bohao YangSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Hanxi LuoSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Zhiwei ZongInstitute of Medical Technology, Peking University Health Science Center, Beijing, China.
Jie ChenSchool of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Ayibaota BahabayiDepartment of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.
Chen LiuDepartment of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China. liuchen-best@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to analyze CD27 expression in various subsets of CD4+ T cells in peripheral blood, explore the functional characteristics of the CD27+ subsets in regulatory T cells (Tregs) and CD4+ T cells, and assess their immunological alterations in newly diagnosed systemic lupus erythematosus (SLE) patients.

methodsPeripheral blood was collected from 34 newly diagnosed, untreated SLE patients and 22 healthy controls. Flow cytometry was used to analyze CD27 expression on T cell subsets, comparing the functional markers between CD27+ and CD27- subsets. CD27 expression on Tregs and total CD4+ T cells in SLE patients and healthy controls were compared. ROC curves were constructed, and areas under the curve (AUCs) was calculated to evaluate the diagnostic value of CD27-related T cell subsets for SLE.

resultsThe proportion of Tregs in the peripheral blood of SLE patients was increased, and CD27 expression was higher in Tregs than in CD4+ T cells in healthy individuals. CD27+ CD4+ T cells exhibited higher CD45RA and lower CD226 expression. CD27+ Tregs showed higher Helios and TIGIT expression and lower CD226 expression. CD27+ cell proportions in both CD4+ T cells and Tregs were significantly reduced in SLE patients. The AUC for CD27-related T cell subsets in diagnosing newly diagnosed SLE ranged from 0.6238 to 0.86.

conclusionCD27

Indexed as

Lupus Erythematosus, SystemicT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsTumor Necrosis Factor Receptor Superfamily, Member 7AdultBiomarkersFemaleHumansImmunophenotypingMaleMiddle AgedYoung AdultBiomarkersTumor Necrosis Factor Receptor Superfamily, Member 7CD27CD4+ T cellsRegulatory T cellsSystemic lupus erythematosus

Identifiers

PMID40381105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.