Evidence map›Paper›PMID 40381092›Full record

ArticleJournal of autism and developmental disorders2025

Autism, Obesity, and PTSD Among Adolescents and Young Adults: An Analysis of National Medicaid Claims Data.

Emily Hotez, Rebecca K Tsevat, Sha Tao, Jenny Mai Phan, Philip Smith, Tammy Shen, Jonas Ventimiglia, Liliana Rivera, Hailey Kissner, Lisa A Croen and 1 more

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily HotezUniversity of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA, USA. ehotez@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-4476-4032
Rebecca K TsevatUniversity of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA, USA.
Sha TaoA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Jenny Mai PhanCenter for Autism, Children's National Hospital, Washington, DC, USA.
Philip SmithA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Tammy ShenUniversity of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA, USA.
Jonas VentimigliaA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Liliana RiveraUniversity of California, Los Angeles (UCLA), David Geffen School of Medicine, Los Angeles, CA, USA.
Hailey KissnerA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
Lisa A CroenDivision of Research, Kaiser Permanente Northern CA, Pleasanton, CA, USA.
Lindsay SheaA.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)T32NS115656 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI BERL, MADISON MEHALANI, SIDOROV, MICHAEL S · 2021 to 2025
$1.8M
Maternal and Child Health Bureau HRSA-23-069NICHD NIH HHS L40 HD106312NICHD NIH HHS P50 HD105328NINDS NIH HHS T32 NS115656
6 · The paper itself

Abstract

Autistic individuals disproportionately experience obesity, cardiovascular disease, diabetes, and a range of other adverse health outcomes, relative to both the general population and those with other developmental conditions. These individuals also disproportionately experience Post-Traumatic Stress Disorder (PTSD). Many of these conditions emerge during adolescence and young adulthood (age 15-30). This study analyzed Medicaid claims data (2008-2019) from autistic (n = 627,586; M age = 17.15 [3.55]) and non-autistic (n = 1,223,161; M age 19.35 [4.56]) adolescent and young adults. Using logistic regression and adjusting for demographic and clinical characteristics, this study: (1) evaluated associations between the presence of autism, obesity, and other health co-morbidities using the Adolescent and Young Adult (AYA) Hope Comorbidity Index; and (2) tested PTSD as a moderator in these associations. Compared with non-autistic beneficiaries, autistic beneficiaries demonstrated 2.12 (95% CI: 2.09, 2.15) and 2.12 (95% CI: 2.09, 2.16) times the odds of having obesity and other health comorbidities, respectively. PTSD moderated these associations such that autism status was more strongly associated with obesity and health co-morbidities among those without a PTSD diagnosis compared to those with a PTSD diagnosis. Autistic adolescents and young adults experience higher rates of obesity, health co-morbidities, and PTSD relative to their non-autistic counterparts. Future work is needed to explore measurement of stress and trauma beyond PTSD diagnoses and elucidate the precise association between stress and trauma with adverse health outcomes in this population.

Indexed as

AdolescentsAutismHealthMedicaidObesityPTSDYoung adults

Identifiers

PMID40381092
PMCPMC12434421

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.