ArticleInternational ophthalmology2025
Evaluation of moxifloxacin penetration into corneal lenticules extracted during SMILE surgery.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the penetration of topically applied moxifloxacin 0.5% in corneal lenticule tissue collected from healthy patients undergoing the Kerato Lenticule Extraction (KLEx) surgery.
methodsThirty-seven eyes of 37 patients received a single drop of moxifloxacin 0.5% before corneal lenticule tissue collection in KLEx surgery. The lenticule samples were divided into three groups according to collection time. Eight lenticules (21.6%) were included in group 1 (0.5 to 1.0 h), 19 lenticules (51.3%) in group 2 (1.0 to 1.5 h), and 10 lenticules (27.0%) in group 3 (1.5 to 2.0 h). The lenticules were stored at -80 °C until analysis. Moxifloxacin concentration in the lenticule tissue was measured using a validated liquid chromatography mass spectrometry (LC-MS/MS) technique.
resultsThe mean corneal lenticule concentration of moxifloxacin was 22.54 ± 13.63 μg/g in group 1, 17.8 ± 10.88 μg/g in group 2, and 9.88 ± 4.2 μg/g in group 3. These concentrations were higher than the minimum inhibitory concentration (MIC) values of bacterial isolates, except Pseudomonas aeruginosa.
conclusionThis study demonstrates that a single preoperative drop of moxifloxacin 0.5% achieves corneal tissue concentrations above the MIC for most bacterial pathogens except Pseudomonas aeruginosa. These results suggest that such prophylactic administration may effectively reduce the risk of post-operative infection in patients undergoing KLEx surgery.
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