Evidence map›Paper›PMID 40381060›Full record

ArticleBiotechnology letters2025

Enhancing terpenoid production in Saccharomyces cerevisiae via cell morphology engineering.

Ke Bi, Siqi Zuo, Jiazhang Lian, Zhinan Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ke BiKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Siqi ZuoKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
Jiazhang LianKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China. jzlian@zju.edu.cn.
Zhinan XuKey Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China. znxu@zju.edu.cn.ORCID http://orcid.org/0000-0001-7833-026X

Funding

Key Research and Development Program of Zhejiang Province 2021C03006Key Science and Technology Development Project of Jinhua 2021-3-029National Key Research and Development Program of China 2021YFC2103200the Agricultural and Social Development Research Project of Hangzhou 202204B01
6 · The paper itself

Abstract

There is a growing interest in establishing yeast as a cell factory for terpenoid production. Given the hydrophobicity of many terpenoids, expanding the intracellular storage pool is an effective strategy to improve titers. In this study, the storage capacity was enhanced by increasing yeast cell size through the knockout of EST1 and SSN8. The influence on lycopene and 7-dehydrocholesterol production were then evaluated. The results demonstrated that EST1 and SSN8 deletion resulted in 4.27- and 3.45-fold improvement on lycopene production, and 1.99- and 1.2-fold improvement on 7-dehydrocholesterol production, respectively. These findings suggest cell enlargement as a promising strategy for enhancing terpenoid production in yeast.

Indexed as

Metabolic EngineeringSaccharomyces cerevisiaeTerpenesGene Knockout TechniquesLycopeneSaccharomyces cerevisiae ProteinsLycopeneSaccharomyces cerevisiae ProteinsTerpenes7-dehydrocholesterolCell enlargementLycopeneSynthetic biologyTerpenoid biosynthesisYeast

Identifiers

PMID40381060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.