ArticleArchives of dermatological research2025
Wound treatment with curcumin prevents hypertrophic scarring and promotes remodeling by inhibiting fibroblast activation and regulating collagen deposition.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Therapeutic Effect of Topical Triamcinolone Acetonide Combined With 10600-nm Ablative Fractional Carbon Dioxide Laser or 1565-nm Non-Ablative Fractional Laser on Hypertrophic Scars in the Rabbit Ear Model.Aesthetic plastic surgery · 2026Article
- A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More and more attention is paid to the prevention of hypertrophic scars (HS). This study aimed to investigate the mechanisms of topical curcumin application in alleviating HS secondary to wounds. Human dermal fibroblasts (HDFs) were cultured with transforming growth factor-β1 and varying concentrations of curcumin for 48 h. The proliferation activity, apoptosis and migration of HDFs were detected by CCK-8 assay, EdU assay, flow cytometry and wound healing assay, respectively. The expression of proteins implicated in fibroblast activation and collagen deposition was determined by Western blotting (WB). Curcumin (25 μmol/L, 28 days) was applied to rabbit ear wounds, and hypertrophic scarring was evaluated grossly and microscopically. We found that curcumin inhibited the proliferation and migration of HDFs and promoted cell apoptosis in a concentration-dependent manner. Curcumin at 10 and 25 μmol/L concentrations reduced the expression of Ki-67 and α-smooth muscle actin and increased cleaved caspase-3 expression and Bax/Bcl-2 ratio. Although the protein levels of collagen-I (COL-I), COL-III, matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were down-regulated, COL-III/COL-I and MMP-2/TIMP-1 ratios were maintained. Curcumin decreased the Manchester scar scale score, scar elevation index and collagen volume fraction of rabbit ear scars. Immunohistochemical results were generally consistent with the WB data. Unlike suppression of TIMP-1 in the entire region of the scar, curcumin reduced MMP-2 expression only in the edge part, which might be related to the alteration of cell polarity and orientation of fibroblasts. In conclusion, curcumin facilitates high-quality scars after wound healing by regulating fibroblast activation and collagen deposition.
Indexed as
Identifiers
40381057What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.