ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025
Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) for paediatric intracranial cavernous malformations: case series and review of the literature.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Single-center longitudinal experience with MRgLITT in pediatric neurosurgery: technical evolution, expanding indications, and advanced MRI-driven planning.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
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Authors and funding
7 authors.
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Abstract
purposeMicrosurgical resection is the standard for treating intracranial cavernous malformations (CMs), but minimally invasive approaches are gaining popularity, particularly for deep-seated lesions and pediatric patients. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) has emerged as a potential alternative to open surgery. This study aims to evaluate the safety and efficacy of MRgLITT for pediatric cavernomas and review existing literature.
methodsA systematic search of MEDLINE (PubMed), Scopus, Embase, and Cochrane databases using terms related to "LITT" and "cavernomas" identified studies reporting MRgLITT outcomes in pediatric patients. Data on demographics, symptoms, lesion characteristics, and outcomes were extracted. A combined database included cases from literature and four treated at our institution, Santobono-Pausilipon Children's Hospital of Naples.
resultsThree studies with eight pediatric cases and four additional institutional cases were analyzed, totaling 12 patients. Outcomes for epilepsy were favorable: two patients achieved Engel class IA, one class IC, and one class II. No recurrences or hemorrhages occurred. Two patients experienced permanent complications-one with partial right superior quadrantanopia and another with unilateral hearing loss.
conclusionMRgLITT offers comparable outcomes to open surgery with reduced invasiveness, particularly for deep-seated lesions. Advances in thermal monitoring, neurophysiological monitoring, and functional MRI integration could further refine this approach, expanding its applications while minimizing complications in pediatric CMs.
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