Trial reportClinical oral investigations2025
Clinical, tomographic, and histological analysis of post-extraction dental sockets filled with particulate dentin or blood clot: pilot study of a randomized clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
10 authors.
Funding
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Abstract
objectiveThis preliminary study aims to compare the clinical, radiological, and histological outcomes of third molar socket repairs after dental extraction with and without the use of particulate dentin graft. MATERIALS AND
methodsTen patients requiring bilateral surgical extraction of impacted lower third molars were selected. One side received a blood clot (control side) and the other an autologous particulate dentin graft (experimental side). Postoperative evaluations at 7 and 21 days assessed pain, edema, trismus, suture dehiscence, and wound edge coaptation. At 120 days, CBCT was used to evaluate bone density, and a biopsy was performed for histological analysis. Data were analyzed using IBM SPSS software with descriptive statistics and paired t-test at a 5% significance level.
resultsAt 21 days, only one case of suture dehiscence occurred on the experimental side, compared to three on the control side. No differences in pain, edema, or trismus were observed between groups. Tomographic analysis showed no significant difference in the distance from the alveolar bone crest to the CEJ, but the experimental group had significantly higher bone density (p = 0.002). Histologically, the experimental side exhibited thicker, denser connective tissue with higher cellularity, collagen production, and multinucleated giant cells, while the control side showed typical connective tissue with fewer multinucleated cells.
conclusionParticulate dentin grafting showed benefits in bone density and clinical stability, with a more advanced histological healing stage. CLINICAL RELEVANCE: Improve post-extraction socket healing, offering a promising alternative to traditional methods, particularly in terms of enhancing bone regeneration and clinical outcomes.
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