ArticleClinical oral investigations2025
Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Calcium Silicate-Based Cements for Vital Pulp Therapy: Integrated Assessment of Radiopacity, Elemental Composition, and 24-h Pulp Cell Responses.Biomimetics (Basel, Switzerland) · 2026Article
- In Vitro Evaluation of Novel Resin-Modified Calcium Silicate Cements for Minimally Invasive Vital Pulp Therapy.International dental journal · 2026Article
- Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Application of the Er:YAG laser in pulpotomy for mature permanent teeth with pulpitis: An animal study.PloS one · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
objectivesTheraCal PT is a novel resin-modified calcium-silicate material introduced for vital pulp therapies. This study aimed to investigate the inflammation and hard tissue formation after pulpotomy treatment with Biodentine and TheraCal PT in inflamed or healthy rat molar teeth.
methodsThis study consisted of six groups (n = 12, 72 teeth): negative control-no preparation (NC); positive control (PC); Biodentine-pulpitis teeth (BD-P), TheraCal PT-pulpitis teeth (TPT-P), Biodentine-healthy teeth (BD-H), TheraCal PT-healthy teeth (TPT-P). For PC, BD-P and TPT-P groups, teeth were induced with lipopolysaccharide for 12 h. Pulpotomy procedure was performed with Biodentine and TheraCal PT. Eight weeks later, pulpal inflammatory cell infiltration and hard tissue formation were evaluated by histological analysis. Pearson's chi-square test was performed.
resultsThere were significant differences among groups for inflammation and hard tissue formation (p <.05). PC group showed moderate to severe inflammation. Biodentine groups showed lower inflammation scores than TheraCal PT groups. Pulpitis-induced groups showed higher inflammation scores than healthy groups. In Biodentine groups, complete hard tissue formation was higher than incomplete hard tissue formation. TheraCal PT groups showed mostly incomplete or no hard tissue formation. Pulpitis-induced groups showed inferior hard tissue formation scores than healthy groups.
conclusionsTheraCal PT as a pulp capping material and inflamed pulp as a pre-treatment tooth condition showed inferior results in pulpotomy treatment. Biodentine exhibited favorable inflammatory pulpal responses and thicker hard tissue formation than TheraCal PT. CLINICAL RELEVANCE: The novel resin-modified calcium-silicate material showed inferior inflammatory cell infiltration and hard tissue formation results in pulpotomy-treated teeth with irreversible pulpitis.
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