Evidence map›Paper›PMID 40380766›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025

Global mitophagy inhibition via BNIP3 ablation is not sufficient to alleviate skeletal muscle impairments in male and female tumor-bearing mice.

Francielly Morena, Ana Regina Cabrera, Toby L Chambers, Pieter J Koopmans, Seongkyun Lim, Stavroula Tsitkanou, Sabin Khadgi, Calvin Peterson, Eleanor R Schrems, Ruqaiza Muhyudin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Sustained loss ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francielly MorenaCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-5019-2125
Ana Regina CabreraCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-9811-3585
Toby L ChambersMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-7567-1819
Pieter J KoopmansMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-4797-5265
Seongkyun LimCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-7075-5909
Stavroula TsitkanouCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-6753-5945
Sabin KhadgiMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0009-0002-8394-624X
Calvin PetersonMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Eleanor R SchremsExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Ruqaiza MuhyudinCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Sepideh ShakeriExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Kevin ZhaoCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Devan MishraCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.
Tyrone WashingtonExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0002-1919-5907
Kevin A MurachMolecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0003-2783-7137
Nicholas P GreeneCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, Arkansas, United States.ORCID 0000-0001-9621-2005

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI intawat nookaew · 2018 to 2026
$23.0M
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIAR01AR075794 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI GREENE, NICHOLAS PERRY · 2020 to 2024
$1.6M
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5R01AR075794HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM125503NIAMS NIH HHS R01 AR075794NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Cancer cachexia (CC) is marked by severe skeletal muscle loss and dysfunction, associated with mitochondrial degeneration. Our previous studies showed induction of the mitophagy marker BNIP3 3-wk post-Lewis lung carcinoma (LLC) induction. We hypothesize that excessive mitophagy contributes to muscle wasting in CC. To test this, we used a

Indexed as

CachexiaCarcinoma, Lewis LungMembrane ProteinsMitophagyMuscle, SkeletalAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMitochondrial ProteinsMuscular AtrophyBNip3 protein, mouseMembrane ProteinsMitochondrial Proteinscachexiafractional synthesis rateslung cancermitochondrial respirationmuscle contractility

Identifiers

PMID40380766
PMCPMC12183643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.