ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Review
- Regulatory effects of hawthorn on lipid metabolic homeostasis: mechanisms, evidences, and perspectives.Frontiers in nutrition · 2026Review
- Colon: a likely middleman connecting the liver, adipose tissue, and gut microbiota in MASLD.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
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8 authors.
Funding
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects ∼40% of adults, but causal mechanisms remain elusive. Preclinical models implicate the gut microbiota in MASLD pathogenesis, yet translation to humans is hampered by variability in microbial composition. We addressed this gap by investigating whether stable, quantitative gut phenotypes, including microbiota encroachment, are pathological features of MASLD. Sigmoid colon biopsies were collected from participants with and without imaging-defined MASLD. Mucus immunostaining was paired with fluorescent in situ hybridization to image and quantify the distance separating bacteria from the colonic epithelium (i.e., encroachment). Secondary outcomes included intestinal permeability, colon histopathology, and insulin resistance. RNA sequencing was combined with weighted gene network correlation analysis to explore correlations between colonic gene expression and clinical endpoints. Microbiota encroachment did not differentiate participants with MASLD (
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