ArticleBMC psychiatry2025
Heart rate variability and heart rate asymmetry in adolescents with major depressive disorder during nocturnal sleep period.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nocturnal Autonomic Dysregulation and Admission-Window Clinical Suicide-Risk Assessment in Hospitalized Children and Adolescents.Journal of clinical medicine · 2026Article
- Psychological Aspects and Mental Health Risks in Children and Adolescents with Congenital Heart Defects-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Smart Devices and Multimodal Systems for Mental Health Monitoring: From Theory to Application.Bioengineering (Basel, Switzerland) · 2026Review
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Authors and funding
9 authors.
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Abstract
backgroundAlthough reduced heart rate variability (HRV) has been observed in adolescents with major depressive disorder (MDD), substantial between-study heterogeneity and conflicting outcomes exist. Moreover, few studies have investigated heart rate asymmetry (HRA) features despite the high sensitivity of nonlinear indices to heart rate fluctuations. This study aimed to investigate the variations in HRV measures, especially the nonlinear features of HRA, among adolescents with MDD during the nocturnal sleep period.
methodsAdolescents with MDD and healthy controls completed the clinical assessment of depressive symptom severity and sleep quality followed by a three-night sleep electrocardiogram (ECG) monitoring. Traditional time-domain and frequency-domain HRV measures, nonlinear HRA measures, and the prevalence of different HRA forms and HRA compensation were calculated.
resultsA total of 61 participants with 154 nocturnal ECG time series were available for analysis. Vagally-mediated HRV measures, such as RMSSD, PNN50, and HF, as well as C1
conclusionAdolescents with MDD suffered a significant decrease in vagal tone compared to healthy controls, and the features focusing on the directionality of heart rate variations may provide further information on cardiac autonomic activity associated with depression.
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