SynthesisJournal of orthopaedic surgery and research2025
Efficacy of decellularized extracellular matrix (dECM) for articular cartilage repair in osteoarthritis (OA): a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- From molecular networks to the clinic: a systems biology-nanomedicine roadmap for osteoarthritis diagnosis, regeneration, and safety-by-design.Discover nano · 2026Review
- Articular Cartilage Tissue Engineering: Cells, Bioinstructive Scaffolds, Immunological Microenvironment, and Emerging Technologies.Bioengineering (Basel, Switzerland) · 2026Review
- Clinical Applications of Stromal Vascular Fraction and Stromal Vascular Matrix for Osteoarthritis: A Commentary.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025Article
- The Protective Effect of Decellularized Extracellular Matrix in Osteoarthritis: AnIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) is a common degenerative joint disease causing chronic pain, disability, and mobility limitations, severely affecting quality of life. Traditional treatments like physical therapy and surgery often have limited efficacy due to side effects, incomplete recovery, and disease progression, highlighting the need for innovative therapies.
methodsWe searched PubMed and Embase from January 1, 2010 to November 1, 2024, preliminary included studies involving animal experiments on the therapeutic effects of decellularized extracellular matrix (dECM) and its derived materials on cartilage defect. After removing duplicates, we conducted a bibliometric analysis. Following the exclusion and evaluation of literature, the random/fixed effects model was employed to perform meta-analysis and obtain Weighted Mean Difference (WMD) of Osteoarthritis Research Society International (OARSI) score and International Cartilage Repair Society (ICRS) score between the dECM treatment group and corresponding control group. We verify the robustness of the results through subgroup analysis and sensitivity analysis, with heterogeneity assessed by Q-test and quantified via I
resultsWe included a total of 10 studies, of which 7 were used for ICRS-based meta-analysis and 3 were used for OARSI-based meta-analysis. The combined mean ICRS of dECM treatment group/control group resulted in an WMD of 2.45 (95% CI: 1.07 to 3.84; I
conclusionsBased on the dual-index meta-analysis, the dECM and relative derivatives have been proved to possess significant cartilage repair function in OA, which can be further explored in tissue regeneration filed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.