Evidence map›Paper›PMID 40380243›Full record

SynthesisSystematic reviews2025

Deficiency of B vitamins in women of childbearing age, pregnant, and lactating women in Brazil: a systematic review.

Tatiane Salgado Galvão de Macedo, Michel Carlos Mocellin, Simone Augusta Ribas, Michelle Teixeira Teixeira, Alessandra da Silva Pereira, Gabriel Montalvão Palermo, Cintia Chaves Curioni

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tatiane Salgado Galvão de MacedoPostgraduate Program in Food, Nutrition and Health, Institute of Nutrition, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. tatiane_galvao@outlook.com.
Michel Carlos MocellinDepartment of Fundamental Nutrition, Nutrition School, Federal University of the State Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Simone Augusta RibasDepartment of Public Health Nutrition, Nutrition School, Federal University of the State Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Michelle Teixeira TeixeiraDepartment of Public Health Nutrition, Nutrition School, Federal University of the State Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Alessandra da Silva PereiraDepartment of Fundamental Nutrition, Nutrition School, Federal University of the State Do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Gabriel Montalvão PalermoNutrition School, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Cintia Chaves CurioniDepartment of Social Nutrition, Institute of Nutrition, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 443024/2019-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.798/2020
6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the prevalence of B-complex vitamin deficiencies in Brazilian women of childbearing age, pregnant women, and lactating women.

methodsThis systematic review analyzed cross-sectional and cohort studies published up to August 2023 and indexed in MEDLINE, SciELO, LILACS, Scopus, Embase, Web of Science, and the Brazilian Digital Library of Theses and Dissertations. Additional data were obtained by contacting researchers from Brazilian public universities. Studies assessing deficiency rates using biochemical markers were included. Two reviewers independently selected studies, extracted data, and assessed methodological quality using the Joanna Briggs Institute tool.

resultsOf the 3772 records identified, 13 studies were included. Only folate (n = 13), B12 (n = 11), and B6 (n = 1) deficiencies were investigated, and all studies were cross-sectional. B12 deficiency prevalence varied widely, reaching up to 29.4%. Folate deficiencies were generally low, with only one study reporting a rate as high as 37%. Other B-complex vitamins were insufficiently studied. Most studies had methodological limitations, particularly small sample sizes. The significant heterogeneity across studies limited the feasibility of a pooled quantitative meta-analysis.

conclusionThere is a clear need for more robust studies across all Brazilian regions to improve understanding of vitamin deficiency rates and to support effective nutritional interventions. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020188474.

Indexed as

LactationVitamin B ComplexVitamin B DeficiencyAdultBrazilCross-Sectional StudiesFemaleFolic AcidFolic Acid DeficiencyHumansPregnancyPrevalenceVitamin B 12 DeficiencyFolic AcidVitamin B ComplexBrazilDeficiency diseasesVitamin B complexVitamin B deficiencyWomen

Identifiers

PMID40380243
PMCPMC12083100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.