Evidence map›Paper›PMID 40380166›Full record

Observational studyBMC endocrine disorders2025

Expression and clinical significance of LncRNA Kcnq1ot1 in type 2 diabetes mellitus patients with osteoarthritis.

Hai Hu, Can Zhou, Binbin Jiang, Song Wu, Ting Cai, Jie Yu, Liguo Zhu, Biao Zhou

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. How Selective are Nanomaterials to Treat Osteoarthritis.International journal of nanomedicine · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hai HuDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Can ZhouDepartment of Orthopedics, Xiangtan Hospital Affiliated to Nanhua University, Xiangtan, 411100, China.
Binbin JiangDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Song WuDepartment of Orthopedics, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Ting CaiDepartment of gastroenterology, Hunan provincial people's hospital, the first affiliated hospital of Hunan Normal University, 61 Jiefang Road, Changsha, 410005, China.
Jie YuDepartment of Orthopedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Wangjing Zhonghuan South Road, Beijing, 100102, Chaoyang District, China.
Liguo ZhuDepartment of Orthopedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Wangjing Zhonghuan South Road, Beijing, 100102, Chaoyang District, China.
Biao ZhouDepartment of Orthopedics, Xiangtan Hospital Affiliated to Nanhua University, Xiangtan, 411100, China. zhoubiao989@126.com.

Funding

City (state) joint research project on traditional Chinese medicine of Hunan Provincial Administration of Traditional Chinese Medicine E2023020Key Projects of the National Natural Science Foundation of China 81930118Major Scientific Research Project of Health high-level Talents in Hunan Province R2023163Project of Xiangtan Science and Technology Bureau SF-YB20221018
6 · The paper itself

Abstract

objectiveWe aimed to investigate the expression of lncRNA Kcnq1ot1 in T2DM patients with OA, as well as its correlation with serum inflammatory factors and clinical outcomes of the patients.

methodsThis prospective observational cohort study included a total of 50 patients with type 2 diabetes mellitus (T2DM), 50 patients with osteoarthritis (OA), and 51 patients with both T2DM and OA between March 2020 and March 2023. The serum TNF-α, interleukin (IL)-6, IL-1β and C-reactive protein (CRP) levels were measured using enzyme-linked immunosorbent assay (ELISA). To determine the expression of LncRNA Kcnq1ot1, RT-qPCR was used. Demographic, clinical statistics, lipid metabolism and nutritional indicators were collected. All data used SPSS 26.0 to statistical analyses.

resultsThe T2DM + OA group had significantly higher BMI and LDLC levels compared to the T2DM group (p < 0.05). The serum levels of LncRNA Kcnq1ot1 were significantly higher in the T2DM + OA group compared to the OA group and T2DM group (p < 0.05). Pearson's analysis supported a positive correlation between LncRNA Kcnq1ot1 and IL-6 and IL-1β levels. In addition, LncRNA Kcnq1ot1 could be a potential biomarker for diagnosing the occurrence of T2DM patients with OA. Moreover, LncRNA Kcnq1ot1, BMI, IL-6, Low density lipoprotein cholesterol (LDLC) were the risk factors for T2DM patients with OA.

conclusionThis study showed that the serum LncRNA Kcnq1ot1 levels was remarkably elevated in T2DM patients with OA. This study might provide new targets and a comprehensive approach to treatment in T2DM patients with OA.

Indexed as

Diabetes Mellitus, Type 2OsteoarthritisPotassium Channels, Voltage-GatedRNA, Long NoncodingAgedBiomarkersClinical RelevanceFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersKCNQ1OT1 long non-coding RNA, humanPotassium Channels, Voltage-GatedRNA, Long NoncodingInflammatory factorsLncRNA Kcnq1ot1OAT2DM

Identifiers

PMID40380166
PMCPMC12082958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.