Evidence map›Paper›PMID 40380159›Full record

ArticleBMC pediatrics2025

Changes in serum levels of Chitinase protein-40 in children with Kawasaki disease and its clinical significance.

Yalin Liu, Shan Sun, Baolong Yu, Qianyun Wang, Hui Liu, Xianli Shao, Huafeng Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yalin LiuPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Shan SunEmergency Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Baolong YuPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Qianyun WangPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Hui LiuPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Xianli ShaoPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Huafeng ZhaoPediatric Internal Medicine Department, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China. zhf123456edu@163.com.

Funding

Weifang Health Committee Nos.WFWSJK-2023-380
6 · The paper itself

Abstract

objectivesKawasaki disease (KD) is an acute immune-mediated vasculitis primarily affecting coronary arteries, with limited specific diagnostic biomarkers available. Chitinase protein-40 (YKL-40), a glycoprotein secreted by neutrophils and macrophages, has been associated with vascular inflammation in cardiovascular diseases. This study aimed to investigate the role of YKL-40 in KD by analyzing its serum levels, correlations with inflammatory markers, and potential as a diagnostic and prognostic biomarker.

methodsSerum YKL-40 and interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA) in 46 children with KD (16 with coronary artery lesions [CAL], 30 without CAL) and 30 healthy controls. Correlations between YKL-40, IL-6, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC) count, and platelet (PLT) levels were analyzed.

resultsYKL-40, IL-6, CRP, ESR, WBC, and PLT levels were significantly elevated in KD patients compared to controls. YKL-40 levels correlated positively with IL-6, CRP, and ESR. A serum YKL-40 threshold of ≥ 71.930 ng/mL predicted CAL with sensitivity and specificity of 0.875 and 0.800, respectively. Combining YKL-40 with IL-6 improved sensitivity and specificity to 0.938 and 0.833.

conclusionsYKL-40 is significantly elevated in KD and correlates with inflammatory markers, suggesting its involvement in disease pathogenesis. It is a promising inflammatory biomarker and independent risk factor for predicting CAL in KD, offering potential for improved diagnosis and prognosis. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Chitinase-3-Like Protein 1Mucocutaneous Lymph Node SyndromeBiomarkersBlood SedimentationCase-Control StudiesChildChild, PreschoolClinical RelevanceC-Reactive ProteinEnzyme-Linked Immunosorbent AssayFemaleHumansInfantInterleukin-6Leukocyte CountMaleBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1C-Reactive ProteinInterleukin-6Chitinase protein-40Coronary artery lesionDiagnostic biomarkersInterleukin-6Kawasaki disease

Identifiers

PMID40380159
PMCPMC12085031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.