Evidence map›Paper›PMID 40380128›Full record

Observational studyBMC neurology2025

Neutrophil-to-albumin ratio as a predictor of mortality in patients with intracerebral hemorrhage: a multicenter retrospective cohort study.

Jun Wan, Sen Zhang, Xiang Yuan, Yuyang Liu, Xin Cheng, Hao Liu, Fengrui Yang, Yinquan Ai, Xiaohong Luo, Yuting Zhong and 2 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jun Wan *Center for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Sen Zhang *Center for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Xiang YuanCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yuyang LiuCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Xin ChengDepartment of Neurosurgery, West Hospital of China, Chengdu, Sichuan, China.
Hao LiuCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Fengrui YangCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yinquan AiCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Xiaohong LuoCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yuting ZhongCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Shiqiao LiuCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Yu ZhangCenter for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China. zhangyu1057@cdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracerebral hemorrhage (ICH) is associated with a poor prognosis. The association between the neutrophil-to-albumin ratio (NAR) with mortality in patients with ICH remains underexplored. This study investigated the relationship between the NAR and mortality in patients with ICH.

methodsA multicenter retrospective observational cohort study was conducted from January 2010 to June 2019. Participants were divided into four groups according to NAR quartiles at admission. Univariable and multivariable logistic regression analyses were used to evaluate the relationship between NAR and 90-day mortality. The predictive power of NAR was compared with neutrophil count and albumin levels using receiver operating characteristic (ROC) curve analysis.

resultsPatients in the highest NAR quartile had significantly greater odds of 90-day mortality (adjusted OR 1.74, 95% CI 1.27-2.39, p < 0.001) compared to those in the lowest quartile. The area under the curve (AUC) for NAR was 0.68, demonstrating superior discriminative ability compared to neutrophil count (AUC 0.64) and albumin (AUC 0.60). These findings were consistent across various subgroups, with multivariate analysis confirming the independent predictive value of NAR for mortality in patients with ICH.

conclusionsElevated NAR was independently associated with increased mortality in patients with ICH. NAR is a promising inflammatory marker that could aid in early risk assessment and guide management strategies for patients with ICH.

Indexed as

Cerebral HemorrhageNeutrophilsSerum AlbuminAgedAged, 80 and overBiomarkersCohort StudiesFemaleHumansLeukocyte CountMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesBiomarkersSerum AlbuminIntracerebral hemorrhageMortalityNeutrophil-to-albumin ratio

Identifiers

PMID40380128
PMCPMC12082963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.