ArticleNature aging2025
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
Erratum issuedAbstract read
In one paragraph
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration.Brain : a journal of neurology · 2026Article
- Article
- Plasma Proteomic Changes in GRN and C9orf72 Frontotemporal Dementia.European journal of neurology · 2026Article
- Plasma proteomics link menopause timing to brain aging and dementia risk.Research square · 2026Article
- Plasma proteomics link menopause timing to brain aging and dementia risk.medRxiv : the preprint server for health sciences · 2026Article
- Decoding Dementia Mechanisms: Identification of Key Oligodendrocyte- Associated Genes through Integrative Bioinformatics and Machine Learning.Current topics in medicinal chemistry · 2026Article
- TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity inInternational journal of molecular sciences · 2025Article
- Design considerations for C9orf72 disease prevention trials.Brain : a journal of neurology · 2025Review
- Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau.Molecular psychiatry · 2025Article
- Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia.Molecular neurodegeneration · 2025Article
- Shared and disease-specific pathways in frontotemporal dementia and Alzheimer's and Parkinson's diseases.Nature medicine · 2025Article
- Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification.Research square · 2025Article
- Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification.medRxiv : the preprint server for health sciences · 2025Article
- Benchmarking the AI-based diagnostic potential of plasma proteomics for neurodegenerative disease in 17,170 people.medRxiv : the preprint server for health sciences · 2025Article
- Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.Communications biology · 2025Article
- FTLD-associated proteomic signatures uncovered.Nature reviews. Neurology · 2025Article
- Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.Brain communications · 2025Article
- Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
72 authors.
Rowan SalonerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. rowan.saloner@ucsf.edu.ORCID http://orcid.org/0000-0002-1351-6183
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3903-9805
Eric B DammerGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2947-7606
Erik C B JohnsonGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0604-2944
Emily W PaolilloDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Amy WiseDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Hilary W HeuerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3776-1685
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-4086-9598
Argentina Lario-LagoDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Julia D WebbDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Jacob W VogelDepartment of Clinical Sciences, SciLifeLab, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-6394-9940
Alexander F SantilloClinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-9717-0820
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-8467-7286
Joel H KramerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Jingyao LiNovartis Institutes for Biomedical Research, Inc, Cambridge, MA, USA.
Joseph LoureiroNovartis Institutes for Biomedical Research, Inc, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7222-9160
Rajeev SivasankaranNovartis Institutes for Biomedical Research, Inc, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3917-0181
Kathleen A WorringerNovartis Institutes for Biomedical Research, Inc, Cambridge, MA, USA.
Nicholas T SeyfriedGoizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-4507-624X
Jennifer S YokoyamaDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7274-2634
Salvatore SpinaDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3570-9143
Lea T GrinbergDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6809-0618
William W SeeleyDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1410-2027
Lawren VandeVredeDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8304-6711
Peter A LjubenkovDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Ece BayramDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6875-4242
Andrea BozokiDepartment of Neurology, University of North Carolina, Chapel Hill, NC, USA.
Danielle BrushaberDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0007-0543-0228
Ciaran M ConsidineDepartment of Neurology, Vanderbilt University, Nashville, TN, USA.
Gregory S DayDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0001-5133-5538
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5958-3445
Kimiko Domoto-ReillyDepartment of Neurology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7396-1633
Kelley FaberIndiana University School of Medicine, National Centralized Repository for Alzheimer's, Indianapolis, IN, USA.
Douglas R GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6195-3241
Tania GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0002-7335-2627
Daniel H GeschwindDepartment of Neurology, University of California, Los Angeles, Los Angeles, USA.ORCID http://orcid.org/0000-0003-2896-3450
Nupur GhoshalDepartments of Neurology and Psychiatry, Washington University School of Medicine, Washington University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6680-6731
Neill Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Chadwick M HalesDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Lawrence S HonigDepartment of Neurology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9703-2265
Ging-Yuek R HsiungDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-8017-0856
Edward D HueyDepartment of Neurology, Columbia University, New York, NY, USA.
John KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Walter KremersDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Maria I LapidDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1163-5584
Suzee E LeeDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Irene LitvanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3485-3445
Corey T McMillanDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7581-6405
Mario F MendezDepartment of Neurology, University of California, Los Angeles, Los Angeles, USA.ORCID http://orcid.org/0000-0001-6441-7989
Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Alexander PantelyatDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6427-7485
Belen PascualDepartment of Neurology, Houston Methodist, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4467-7406
Joseph MasdeuDepartment of Neurology, Houston Methodist, Houston, TX, USA.
Henry L PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Peter PressmanDepartment of Neurology, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-1760-1286
Rosa RademakersVIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium.
Eliana Marisa RamosDepartment of Neurology, University of California, Los Angeles, Los Angeles, USA.
Katya RascovskyDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-1810-9763
Rodolfo SavicaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Allison SnyderNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1857-928X
Anna Campbell SullivanGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
M Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-5944-8497
Marijne VandeberghVIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-9645-2615
Brad F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4153-8187
Howie J RosenDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Julio C RojasDepartment of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Adam L Boxer *Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Kaitlin B Casaletto *Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
ALLFTD Consortium
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MResearch Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MAlzheimer's Association AARF-22-974065Alzheimer's Association AARF-23-1145318Alzheimer's Association AARG-20-683875Hjärnfonden (Swedish Brain Foundation) FO2021-0293Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2022-0231Larry L. Hillblom Foundation (Larry L. Hillblom Foundation, Inc.) 2018-A-006-NETLarry L. Hillblom Foundation (Larry L. Hillblom Foundation, Inc.) 2018-A-025-FELNIA NIH HHS K23 AG059888NIA NIH HHS K23 AG061253NIA NIH HHS K23 AG073514NIA NIH HHS K23 AG084883NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG023501NIA NIH HHS R00 AG073453NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG032306NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG058233NIA NIH HHS R01 AG072475NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NINDS NIH HHS U54 NS092089Swedish Parkinson's Disease Association | Parkinsonfonden (Parkinson Foundation) 1412/22U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U54NS092089U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG016976U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG019724U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG032306U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG038791U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) AG058233U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K23AG059888U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K23AG061253U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K23AG073514U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K24AG045333U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG032289U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U01AG045390U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) U19AG063911Vetenskapsrådet (Swedish Research Council) 2022-00775
Abstract
The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN and MAPT) compared with 39 non-carrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN) and extracellular matrix (particularly in MAPT) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules. The generalizability of genetic FTLD proteomic signatures was tested and confirmed in independent cohorts of (1) sporadic progressive supranuclear palsy-Richardson syndrome and (2) frontotemporal dementia spectrum clinical syndromes. Network-based proteomics hold promise for identifying replicable molecular pathways in adults living with FTLD. 'Hub' proteins driving co-expression of affected modules warrant further attention as candidate biomarkers and therapeutic targets.
Indexed as
Frontotemporal Lobar DegenerationProteomeAdultAgedBiomarkersC9orf72 ProteinFemaleHumansMaleMiddle AgedMutationProgranulinsProteomicstau ProteinsBiomarkersC9orf72 ProteinC9orf72 protein, humanGRN protein, humanMAPT protein, humanProgranulinsProteometau Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.