ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Beyond the womb: prenatal MRI's prognostic abilities for morbidity and mortality in neonates with omphaloceles.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Prenatal and Postnatal Determinants of Outcome in Neonates with Omphalocele: A 25-Year Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Prenatal MRI abdominal volumetrics and outcomes after early surgery or paint-and-wait for giant omphalocele.Frontiers in pediatrics · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundManaging omphaloceles poses challenges in prenatal consultation and perinatal care. We hypothesized that specific fetal MRI findings could predict morbidity and mortality in these patients.
methodsWe analyzed fetal MRI studies demonstrating omphaloceles from 2006 to 2022 and conducted a retrospective review of medical records. Predictor variables were correlated with outcomes using univariate and multivariate analyses, and Receiver Operating Characteristic (ROC) curves were optimized with Youden's J statistic.
resultsAmong 46 omphalocele patients, 89% survived to birth, with an overall mortality rate of 37%. Significant predictors of mortality included stomach/spleen herniation, severe anomalies, omphalocele-associated syndromes, membrane rupture, lower observed/expected total fetal lung volume (O/E TFLV), and increased percentage of liver herniation. The need for deferred repair correlated with liver/stomach herniation and "giant-omphalocele." ROC analysis identified mortality cut points at O/E TFLV < 42% and liver herniation >77%, while deferred repair was indicated at liver herniation >51%.
conclusionThis study identified prenatal MRI findings associated with mortality and deferred repair, aiding in risk prediction and family counseling.
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