Trial reportSurgical endoscopy2025
Sequential injection-electrocoagulation vs. traditional electrocoagulation haemostasis during endoscopic submucosal dissection: a randomized controlled trial.
Trial report in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Subspecialty-specific foundation model for intelligent gastrointestinal pathology.NPJ digital medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundElectrocoagulation with an electrosurgical knife is the traditional approach to achieve haemostasis during endoscopic submucosal dissection (ESD), as bleeding may obscure the operative field and increase the risks of muscle injury and perforation.
aimsThe aim of this study was to assess the efficacy and safety of the sequential injection-electrocoagulation procedure during ESD.
methodsIn this randomized controlled trial, 69 patients undergoing upper gastrointestinal ESD were randomized to either the control group (traditional electrocoagulation) or the experimental group ("Sequential injection-electrocoagulation" method) from September 2023 to June 2024. Two endoscopists scored the visibility of each bleeding point from 1 (undetectable) to 4 (easily detectable).
resultsThe median time to haemostasis at each bleeding point was 17 (11-23) seconds in the experimental group and 22 (14.5-41) seconds in the control group (P < 0.001). The visibility scores were significantly higher in the experimental group than in the control group (3.24 ± 0.63 vs. 2.82 ± 0.57) (P < 0.001). Muscle injuries occurred more frequently in the control group (P = 0.003). Unfortunately, there was one case of perforation in the control group caused by haemostasis.
conclusionThe sequential injection-electrocoagulation strategy shortened the time to hemostasis during ESD, improved the visibility of bleeding points, and minimized the risks of muscle injury and perforation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.