ArticlePediatric research2025
Correlation between histologic chorioamnionitis and severe retinopathy of prematurity.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The association of chorioamnionitis with intraventricular hemorrhage and long-term outcome in very preterm neonates.Frontiers in pediatrics · 2026Article
- Predictive Value of Postnatal Weight Gain Rate for Severe Retinopathy of Prematurity in Preterm Infants: A Retrospective Analysis.Journal of multidisciplinary healthcare · 2025Article
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5 authors.
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Abstract
backgroundRetinopathy of prematurity (ROP) is influenced by factors, including gestational age (GA), oxygen exposure, and chorioamnionitis. However, the association between histologic chorioamnionitis (HCA) and ROP remains controversial. This study aimed to investigate the association between HCA and severe ROP.
methodsThis retrospective cohort study utilized data from the National Korean Neonatal Network registry, focusing on infants with birthweights < 1500 g and GA < 32 weeks. Univariate and multivariate logistic regression analyses assessed the association between HCA and severe ROP. Sub-cohort analyses were performed to evaluate the effect of HCA on severe ROP across different GA groups.
resultsInfants in the HCA cohort had lower GA and birth weights, with a higher prevalence of any-stage and severe ROP compared to those in the without-HCA cohort. However, multivariate logistic regression showed an inverse association between HCA and severe ROP. Sub-cohort analyses revealed that HCA was associated with an increased risk of severe ROP in infants born at 26-28 and 28-31 weeks, while no significant association was observed in infants born at 23-25 weeks.
conclusionsHCA may reduce the risk of severe ROP, suggesting that intrauterine inflammation could play a protective role. Further research is needed to elucidate underlying mechanisms. IMPACT: Retinopathy of prematurity (ROP) is influenced by numerous perinatal and postnatal factors, including low gestational age, oxygen exposure, and chorioamnionitis. However, the association between chorioamnionitis and ROP remains controversial. Our study showed that histologic chorioamnionitis (HCA) was negatively correlated with severe ROP in preterm infants, even after adjusting for confounding factors such as gestational age and birth weight. These findings suggest that HCA may have a protective effect against severe ROP, potentially mediated by inflammatory markers.
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