Evidence map›Paper›PMID 40379835›Full record

ArticleNPJ digital medicine2025

The DRAGON benchmark for clinical NLP.

Joeran S Bosma, Koen Dercksen, Luc Builtjes, Romain André, Christian Roest, Stefan J Fransen, Constant R Noordman, Mar Navarro-Padilla, Judith Lefkes, Natália Alves and 18 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. AI assistance in tumor multidisciplinary teams.ESMO real world data and digital oncology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Joeran S BosmaDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. Joeran.Bosma@radboudumc.nl.
Koen DercksenDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Luc BuiltjesDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Romain AndréDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Christian RoestDepartment of Radiology, University Medical Center Groningen, Groningen, The Netherlands.
Stefan J FransenDepartment of Radiology, University Medical Center Groningen, Groningen, The Netherlands.
Constant R NoordmanDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Mar Navarro-PadillaDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Judith LefkesComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Natália AlvesDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Max J J de GrauwDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Leander van EekelenComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Joey M A SpronckComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Megan SchuurmansDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Bram de WildeDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Ward HendrixDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Witali AswolinskiyComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Anindo SahaDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Jasper J TwiltMinimally Invasive Image-Guided Intervention Center, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Daan GeijsComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Jeroen VeltmanDepartment of Radiology, Ziekenhuisgroep Twente, Almelo, The Netherlands.
Derya YakarDepartment of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Maarten de RooijDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Francesco CiompiComputational Pathology Group, Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Alessa HeringDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Jeroen GeerdinkDepartment of Health & Information Technology, Ziekenhuisgroep Twente, Almelo, The Netherlands.
Henkjan HuismanDiagnostic Image Analysis Group, Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
DRAGON consortium

Funding

European Union HORIZON-HLTH-2022: COMFORT 101079894Health~Holland LSHM20103Horizon 2020 PANCAIM project (101016851)Horizon 2020 ProCAncer-I project (952159)Junior Researcher Grant Radboud Institute for Health Sciences and Jeroen Bosch Ziekenhuis RIHS JO 18.51773Nederlandse Organisatie voor Wetenschappelijk Onderzoek NWO-KIC-Siemens HealthyAI (KICH3.LTP.20.006)Nederlandse Organisatie voor Wetenschappelijk Onderzoek VIDI grant (number 18388)
6 · The paper itself

Abstract

Artificial Intelligence can mitigate the global shortage of medical diagnostic personnel but requires large-scale annotated datasets to train clinical algorithms. Natural Language Processing (NLP), including Large Language Models (LLMs), shows great potential for annotating clinical data to facilitate algorithm development but remains underexplored due to a lack of public benchmarks. This study introduces the DRAGON challenge, a benchmark for clinical NLP with 28 tasks and 28,824 annotated medical reports from five Dutch care centers. It facilitates automated, large-scale, cost-effective data annotation. Foundational LLMs were pretrained using four million clinical reports from a sixth Dutch care center. Evaluations showed the superiority of domain-specific pretraining (DRAGON 2025 test score of 0.770) and mixed-domain pretraining (0.756), compared to general-domain pretraining (0.734, p < 0.005). While strong performance was achieved on 18/28 tasks, performance was subpar on 10/28 tasks, uncovering where innovations are needed. Benchmark, code, and foundational LLMs are publicly available.

Identifiers

PMID40379835
PMCPMC12084576

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.